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Full
Text Sections
Abstract
Introduction
Pathogens
and Their Hosts
Invasion:
Getting In
Pushing
the Right Buttons
Nurturing
the Parasite
Opposing
Forces
Leaving
the Infected Cell
Assisted
Apoptosis
New
Weapons Against Disease
Acknowledgments
and Bibliography
Suggested
Links
Julie
Theriot’s lab at Stanford
Brett Finlay’s
lab at the Univ. of British Columbia
WWW
Virtual Library’s apoptosis resources page
FDA Bad Bug Book:
Listeria
FDA Bad Bug Book:
Shigella
Pascale
Cossart
A
propos de E-cadherin (in French)
National Institute of Allergy and
Infectious Diseases
World
Health Organization information on infectious diseases
National Center for Infectious
Diseases (CDC)
September-October,
2001
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Pathogens,
Host-Cell Invasion and Disease
Invading pathogens can co-opt even the cells of
the immune system. New anti-infective drugs may arise from an understanding
of this chemical warfare
Erich Gulbins and Florian Lang
Keywords:
Immunology, infectious
disease, pathogens, microorganisms, apoptosis, Listeria, Plasmodium
Abstract:
If you were a pathogen under attack from the immune system—say,
a food-borne Salmonella or Listeria bacterium—you’d want to duck into
a host cell to take some nourishment and replicate under cover, invisible
to passing patrols. But this entails work—and risk. The host cell
may commit suicide, leaving you vulnerable to passing macrophages,
or the host may evolve a defense, as in the case of the resistance
to malaria conferred by sickle-cell disease. Gulbins and Lang study
pathogen–host cell invasion interactions in hope of developing treatments
for infectious disease that mimic host-cell resistance, and thus prevent
the development of drug resistance that hampers the effectiveness
of antibiotics.
Erich
Gulbins is an associate professor in the Department
of Immunology at St. Jude Children´s Research Hospital in Memphis.
He has studied medicine in Heidelberg and worked at the La Jolla Institute
for Allergy and Immunology and the University of Tübingen. Florian
Lang is professor of physiology and chair of the
department at the University of Tübingen in Germany. He studied medicine
in Munich and Glasgow and previously worked at the University of Innsbruck,
the Mayo Clinic, Yale University, the University of Naples and the
Max Planck Institute, Frankfurt. Both authors are cell physiologists
with specific interests in the physiology of host cells invaded by
pathogens. Addresses: (for Gulbins) Department of Immunology, St.
Jude Children’s Research Hospital, 332 North Lauderdale, Memphis,
TN 38105, Internet: erich.gulbins@uni-tuebingen.de;
(for Lang) Department of Physiology, University of Tübingen, Gmelinstrasse
5, 72076 Tübingen, Germany, Internet:florian.lang@uni-tuebingen.de
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