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Process Optimization in 
Drug Discovery
The Creation of a Discovery Factory by Applying Manufacturing Concepts to Genomics, Combinatorial Chemistry and Assay Development
 1. Pitfalls and Bottleneck in Materials Management - 
EMAX Solutions Partners
  • Compound Management Challenge
  • Solutions to Materials and Substance Handling
  • Compound Management: The Hub of Drug Research
  • A Typical Screening Procedure
  • Inventory Management Software: The Missing Link
  • The Compound Management Solution
  • Compound Management Solutions Drive Process Improvement
  • Open And Integrated Operations

2. High Velocity Laboratory - Applying Manufacturing Process Systems to Research - Zymark Corporation

  • Research Applications of Manufacturing Principles
  • Pipeline Velocity
  • Traditional Departmental Manufacturing
  • Cellular Manufacturing
  • Pull Systems
  • The Visual Factory
  • Process Analysis
  • From the Manufacturing Plant to the Discovery Factory

3. High Throughput Target Discovery and Validation - Maximizing Productivity in Genomics -
Millennium Pharmaceuticals

  • Industrialization of Target Identification and Validation
  • The Structure of a Research Organization
  • Components of a Self-Learning Discovery Effort
  • The Old Paradigm of Disease Target Discovery
  • The New Paradigm of Disease Target Discovery
  • The New Paradigm of Target Validation and Lead Generalization
  • Academic Collaborations to Procure Technology
  • Challenges in the Post-Genomic Era
  • Building an Industrialized Target Discovery Process
  • Integrated Information and Knowledge Management Systems
  • Resource Allocation Management
  • Specific Goals of Production Teams
  • Industrialization of Later Stages in Drug Discovery

4. An Operations Approach to Combinatorial Chemistry and Assay Development - Axys Pharmacuticals

  • The Task of Optimizing Combinatorial Chemistry Operations
  • The Insatiable Demand for Chemical Compounds
  • A Laundry List of Problems and Inefficiencies
  • The Need for Speed in Chemical Synthesis
  • Re-Organization: Separating Development and Production
  • Protocol Development is the Rate Limiting Step
  • Quality Control for Chemical Libraries
  • High Quality Chemical Libraries
  • Combinatorial Chemistry is a Process Development Function
  • Optimization of Lead Discovery Timeline
  • Full Automation vs. Partial Automation
  • Database Quality and Materials Management
  • of Balancing Powers to Conduct R&D Quality Control
  • Organizational Buy-in to Project Management
  • Follow-up Libraries
  • Reintegration of the Chemical Development and Project Teams
  • Overcoming Cultural Obstacles to Productivity
  • The Future of Combinatorial Chemistry

Report Format
• 72 pages of transcripts and commentaries
• 25+ exhibits
• 25+ weblinks
• Fully indexed and searchable for easy navigation

Available as CD-ROM and a printed hardcopy

Who Should Read This Report?
Executives in Project Management, Program Management, Discovery or Clinical Operations working in Pharmaceutical and Biotechnology Companies

Price -  $895 

Published in September, 1999

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