Lysine
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Lysine | |
---|---|
Systematic name | (S)-2,6-Diaminohexanoic acid |
Abbreviations | Lys K |
Chemical formula | C6H14N2O2 |
Molecular mass | 146.19 g/mol |
Melting point | 224 °C |
Specific rotation | +14.6° |
Isoelectric point | 9.74 |
pKa | 2.15 9.16 10.67 |
CAS number | [56-87-1] |
EINECS number | 200-294-2 |
SMILES | NCCCCC(N)C(=O)O |
Disclaimer and references |
Lysine is one of the 20 amino acids normally found in proteins. With its 4-aminobutyl side-chain, it is classified as a basic amino acid, along with arginine and histidine. It is an essential amino acid, and the human nutritional requirement is 1–1.5 g daily. A deficiency in lysine can result in a deficiency in niacin (which is a B Vitamin). This can cause the disease pellagra. Lysine can also be used as a nutritional supplement to help against herpes.
Lysine is the limiting amino acid in all cereal grains, but is plentiful in all pulses (legumes). Fish are also quite rich in lysine. Plants that contain significant amounts of lysine include:
- Buffalo Gourd (10,130–33,000 ppm) in seed
- Berro, Watercress (1,340–26,800 ppm) in herb.
- Soybean (24,290–26,560 ppm) in seed.
- Carob, Locust Bean, St.John's-Bread (26,320 ppm) in seed;
- Common Bean (Black Bean, Dwarf Bean, Field Bean, Flageolet Bean, French Bean, Garden Bean, Green Bean, Haricot, Haricot Bean, Haricot Vert, Kidney Bean, Navy Bean, Pop Bean, Popping Bean, Snap Bean, String Bean, Wax Bean) (2,390–25,700 ppm) in sprout seedling;
- Ben Nut, Benzolive Tree, Drumstick Tree, Horseradish Tree, Jacinto (Sp.), Moringa, West Indian Ben (5,370–25,165 ppm) in shoot.
- Lentil (7,120–23,735 ppm) in sprout seedling.
- Asparagus Pea, Goa Bean, Winged Bean (21,360–23,304 ppm) in seed.
- Fat Hen (3,540–22,550 ppm) in seed.
- Lentil (19,570–22,035 ppm) in seed.
- White Lupin (19,330–21,585 ppm) in seed.
- Black Caraway, Black Cumin, Fennel-Flower, Nutmeg-Flower, Roman Coriander (16,200–20,700 ppm) in seed.
- Spinach (1,740–20,664 ppm) in slant.
- Amaranth, Quinoa
Lysine can undergo posttranslational modification in protein molecules, often by methylation or acetylation. Collagen contains hydroxylysine which is derived from lysine. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Lysine is metabolised in mammals to give Acetyl-CoA, via an initial transamination with α-ketoglutarate. The bacterial degradation of lysine yields cadaverine by decarboxylation.
Some individuals have found that taking lysine supplements may reduce the frequency of canker sores.
Trivia
In the film Jurassic Park, as a security measure, the dinosaurs have their DNA modified so that they cannot produce lysine and must be supplied it by the park's feeding system, otherwise they will eventually die.
Sources
- Much of the information in this article has been translated from German Wikipedia.
- Lide, D. R. (Ed.) (2002) CRC Handbook of Chemistry and Physics (83rd Edn.), Boca Raton (FL):CRC Press. ISBN 0-8493-0483-0.
Lysine is very common in the basmement membranes of aqautic animals
External links
- Lysine biosynthesis (early stages)
- Lysine biosynthesis (later stages)
- Lysine catabolism
- Computational Chemistry Wiki
Alanine | Arginine | Asparagine | Aspartic acid | Cysteine | Glutamic acid | Glutamine | Glycine | Histidine | Isoleucine | Leucine | Lysine | Methionine | Phenylalanine | Proline | Serine | Threonine | Tryptophan | Tyrosine | Valine |
Essential amino acid | Protein | Peptide | Genetic code |