Karyopherin

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Karyopherins are a group of proteins involved in transporting molecules through the pores of the nuclear envelope (the membrane around a cell's nucleus).

Karyopherins, which may act as importins or exportins, are part of the Importin-β super-family which all share a similar three-dimensional structure.

They belong to 9.A.14 The Nuclear Pore Complex Family in TCDB.

Contents 1 Cycle 2 Genes 3 Additional images 4 External links

[edit] Cycle

For example,

• importin beta + adapter + cargo protein (cytoplasm)-->(karyoplasm)
• importin beta + adapter + RanGTP (karyoplasm)-->(cytoplasm)
• Ran-GTP --> RanGDP + P

[edit] Genes

• KPNA1
• KPNA2
• KPNA3
• KPNA4
• KPNA5
• KPNA6
• KPNB1

[edit] Additional images

The Ran-GTP cycle

[edit] External links

• MeSH Karyopherins
• Illustrations at berkeley.edu
• Karyopherin animations
• Karyopherin illustrations

v • d • e Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter	A1, A2, A3, A4, A7, A12, B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11, C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C11, D1, D2, D3, D4, E1, F1, F2, G1, G2, G4, G5/G8, G5, G8
Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 7A1, 7A3, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A8, 10A1, 10A2, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A3, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A37, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 27A2, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O4A1
Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9
Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Karyopherin)