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Matchday 4 - 03 December 2008
| Group | Home | Away | ||
|---|---|---|---|---|
| A | Man. City | 0-0 | PSG | Report » |
| A | Twente | 2-1 | Schalke | Report » |
| B | Metalist | 1-0 | Olympiacos | Report » |
| B | Hertha | 0-1 | Galatasaray | Report » |
| C | Standard | 3-0 | Sampdoria | Report » |
| C | Sevilla | 3-0 | Partizan | Report » |
| D | Spartak Moskva | 1-2 | NEC | Report » |
| D | Udinese | 2-1 | Dinamo Zagreb | Report » |
Matchday 4 - 04 December 2008
| Group | Home | Away | ||
|---|---|---|---|---|
| E | Wolfsburg | 3-2 | Portsmouth | Report » |
| E | Heerenveen | 1-2 | Braga | Report » |
| F | Slavia Praha | 0-2 | Hamburg | Report » |
| F | Aston Villa | 1-2 | Žilina | Report » |
| G | Valencia | 1-1 | Club Brugge | Report » |
| G | København | 1-1 | Rosenborg | Report » |
| H | Lech | 1-1 | Deportivo | Report » |
| H | Nancy | 3-4 | CSKA Moskva | Report » |
