Phenindione

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Phenindione
Systematic (IUPAC) name
2-phenyl-1H-indene-1,3(2H)-dione
Identifiers
CAS number	83-12-5
ATC code	B01AA02
PubChem	4760
DrugBank	APRD00166
Chemical data
Formula	C15H10O2
Mol. mass	222.239 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	88%
Metabolism	?
Half life	5 to 10 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	D(AU) Passes into breast milk
Legal status
Routes	Oral

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Hypersensitivity has been observed.^[1]

[edit] References

[edit] External links

• DDB 30536

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01) Antiplatelet drugs Glycoprotein IIb/IIIa inhibitors Abciximab • Eptifibatide • Tirofiban ADP receptor/P2Y12 inhibitors (Thienopyridines) Clopidogrel • Ticlopidine • Prasugrel Prostaglandin analogue (PGI2) Beraprost • Prostacyclin • Iloprost • Treprostinil COX inhibitors Acetylsalicylic acid/Aspirin # • Aloxiprin • Carbasalate calcium Other Ditazole • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal Anticoagulants Vitamin K antagonists (inhibit II, VII, IX, X) coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol (Dicumarol) • Ethyl biscoumacetate • Phenprocoumon • Warfarin 1,3-Indandiones: Clorindione • Diphenadione • Phenindione other: Tioclomarol Factor Xa inhibitors (with some II inhibition) Heparin group/ glycosaminoglycans/ (bind antithrombin) low molecular weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin) oligosaccharides (Fondaparinux, Idraparinux) heparinoid (Danaparoid, Sulodexide, Dermatan sulfate) Direct Xa inhibitors xabans (Apixaban, Otamixaban, Rivaroxaban) Direct thrombin (II) inhibitors bivalent: Hirudin (Bivalirudin, Lepirudin, Desirudin) univalent: Argatroban • Dabigatran • Melagatran • Ximelagatran Other Defibrotide • Ramatroban • Antithrombin III • Protein C (Drotrecogin alfa) Thrombolytic drugs/ fibrinolytics plasminogen activators: TPA (Alteplase, Reteplase, Tenecteplase) • UPA (Urokinase, Saruplase) • Streptokinase # • Anistreplase • Monteplase other serine endopeptidases: Ancrod • Fibrinolysin Brinase Non-medicinal Citrate • EDTA • Oxalate #WHO-EM. †Undergoing clinical trials, not FDA approved. ‡Withdrawn from market. §Development halted.