| Title | Release Date | Publisher | Platform |
| Sam & Max Season One | 08.26.2008 | Telltale Games | Wii |
| Samba De Amigo | 08.19.2008 | Sega of America | Wii |
| Samurai Warriors: Katana | 01.15.2008 | KOEI | Wii |
| Sega Bass Fishing | 02.26.2008 | Sega of America | Wii |
| Sega Superstars Tennis | 03.18.2008 | Sega of America | Wii |
| Shaun White Snowboarding: Road Trip | 11.18.2008 | CokeM Interactive | Wii |
| Shrek The Third | 05.15.2007 | Activision | Wii |
| SimCity Creator | 09.22.2008 | Electronic Arts | Wii |
| SIMPLE Series | | D3 | Wii |
| Skate It | 11.18.2008 | Crave Entertainment | Wii |
| Smarty Pants | 11.13.2007 | Electronic Arts | Wii |
| Sonic and the Secret Rings | 02.20.2007 | Sega of America | Wii |
| Sonic Riders: Zero Gravity | 01.08.2008 | Sega of America | Wii |
| Sonic Unleashed | 11.04.2008 | Sega of America | Wii |
| Sonic Wild Fire | | | Wii |
| Soulcalibur Legends | 11.20.2007 | Namco Bandai Games America | Wii |
| Spider-Man 3 | 05.04.2007 | Activision | Wii |
| Spider-Man: Friend or Foe | 10.02.2007 | Activision | Wii |
| SpongeBob Squarepants: Creature from the Krusty Krab | | | Wii |
| SpongeBob SquarePants: Creature From the Krusty Krab | 11.13.2006 | THQ | Wii |
| Spray | 12.09.2008 | Tecmo | Wii |
| SSX Blur | 02.27.2007 | Electronic Arts | Wii |
| Star Trek: Conquest | 11.20.2007 | Bethesda Softworks | Wii |
| Star Wars The Clone Wars: Lightsaber Duels | 11.18.2008 | LucasArts | Wii |
| Super Mario Galaxy | | | Wii |
| Super Mario Galaxy | 11.12.2007 | Nintendo of America | Wii |
| Super Monkey Ball: Banana Blitz | | | Wii |
| Super Paper Mario | 04.09.2007 | Nintendo of America | Wii |
| Super Smash Bros. Brawl | 03.09.2008 | Nintendo of America | Wii |
| Super Smash Bros. Brawl | | | Wii |
| Super Swing Golf | | Tecmo | Wii |
| Super Swing Golf Season 2 | 12.11.2007 | Tecmo | Wii |
| Surf's Up | 05.29.2007 | Ubi Soft | Wii |