Bacillary angiomatosis
From Wikipedia, the free encyclopedia
| Bacillary angiomatosis | |
|---|---|
| Classification and external resources | |
| ICD-10 | A44.8 (ILDS A44.85), B20.1 (ILDS B20.11) |
| ICD-9 | 088.0 |
| DiseasesDB | 2173 |
| eMedicine | derm/44 |
| MeSH | D016917 |
Bacillary angiomatosis (BA) is a form of angiomatosis associated with bacteria of the Bartonella genus.
Contents |
[edit] Causes
It is caused by either Bartonella henselae or Bartonella quintana.[1]
- Bartonella henselae is most often transmitted through a cat scratch or bite,[2] though ticks and fleas may also act as a vector.
- Bartonella quintana is usually transmitted by lice.
It can manifest in people with AIDS,[3] and rarely appearing in those who are immunocompetent.[citation needed]
[edit] Presentation
BA is characterised by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs.
[edit] Symptoms
Cutaneous BA is characterised by the presence of lesions on or under the skin. Appearing in numbers from one to hundreds, these lesions may take several forms:
- papules or nodules which are red, globular and non-blanching, with a vascular appearance
- purplish nodules sufficiently similar to Kaposi's sarcoma that a biopsy may be required to verify which of the two it is
- a purplish lichenoid plaque
- a subcutaneous nodule which may have ulceration, similar to a bacterial abscess
While cutaneous BA is the most common form of BA, BA can also affect several other parts of the body, such as the brain, bone, bone marrow, lymph nodes, gastrointestinal tract, respiratory tract, spleen and liver. Symptoms vary depending on which parts of the body are affected; for example, those whose livers are affected may have an enlarged liver and fever, while those with osseous BA will experience intense pain in the affected area.
[edit] Treatment and prevention
While curable, it is potentially fatal if not treated.
BA responds dramatically to several antibiotics. Usually, erythromycin will cause the skin lesions to gradually fade away in the next four weeks, resulting in complete recovery. Doxycycline may also be used. However, if the infection does not respond to either of these, the medication is usually changed to tetracycline. If the infection is serious, then a bactericidal medication may be coupled with the antibiotics.
If a cat is carrying Bartonella henselae, then it may not exhibit any symptoms. Cats may be bacteremic for weeks to years, but infection is more common in young cats. Transmission to humans is thought to occur via flea feces inoculated into a cat scratch or bite, and transmission between cats occurs only in the presence of fleas. Therefore, elimination and control of fleas in the cat's environment are key to prevention of infection in both cats and humans.
[edit] History
Bacillary angiomatosis was first described by Stoler and associates in 1983. Being unaware of its infectious origin, it was originally called epithelioid angiomatosis.
[edit] See also
[edit] References
- ^ Koehler JE, Sanchez MA, Garrido CS, et al. (December 1997). "Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis". N. Engl. J. Med. 337 (26): 1876–83. doi:. PMID 9407154. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=9407154&promo=ONFLNS19.
- ^ Mateen FJ, Newstead JC, McClean KL (July 2005). "Bacillary angiomatosis in an HIV-positive man with multiple risk factors: A clinical and epidemiological puzzle". Can J Infect Dis Med Microbiol 16 (4): 249–52. PMID 18159553.
- ^ Gasquet S, Maurin M, Brouqui P, Lepidi H, Raoult D (1998). "Bacillary angiomatosis in immunocompromised patients.". AIDS 12 (14): 1793–803. doi:. PMID 9792380.
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