| Title | Release Date | Publisher | Platform |
| S.W.A.T. | 07.25.2005 | Sony | PSP |
| Sahara | 08.30.2005 | Paramount Pictures | PSP |
| Samurai Warriors: State of War | 03.07.2006 | KOEI | PSP |
| Saw | | Lion's Gate | PSP |
| Scarface | 10.06.2006 | Vivendi Games | PSP |
| Scooby Doo! Who's Watching Who? | 10.09.2006 | THQ | PSP |
| Secret Agent Clank | 06.17.2008 | Sony Computer Entertainment | PSP |
| Secret Agent Clank | 06.17.2008 | Sony Computer Entertainment | PSP |
| Sega Genesis Collection | 11.16.2006 | Sega of America | PSP |
| Sega Rally Revo | 10.09.2007 | Sega of America | PSP |
| Shrek Smash and Crash | 12.12.2006 | Activision | PSP |
| Sid Meier's Pirates! | 01.22.2007 | Take 2 Interactive | PSP |
| Silent Hill Experience | 04.11.2006 | Konami | PSP |
| Silent Hill Origins | 11.06.2007 | Konami | PSP |
| Silent Hill Origins | | Konami | PSP |
| Silent Hill: Origins - Used | | GameStop.com | PSP |
| Simpsons: The Game - Used | | GameStop.com | PSP |
| Sims 2: Castaway - Used | | Electronic Arts | PSP |
| Sin City | 08.16.2005 | Buena Vista Home Video | PSP |
| Smart Bomb | | EIDOS Interactive | PSP |
| Smash Court Tennis 3 | 07.16.2007 | Namco Bandai Games America | PSP |
| Snatch | 08.23.2005 | Sony | PSP |
| Snoopy vs. the Red Baron | | | PSP |
| Snoopy vs. The Red Baron | 10.24.2006 | Namco Bandai Games | PSP |
| SOCOM U. S. Navy Seals Fireteam Bravo | 11.08.2005 | Sony Computer Entertainment | PSP |
| SOCOM US Navy Seals Fireteam Bravo 2 | 11.07.2006 | Sony Computer Entertainment | PSP |
| SOCOM US Navy Seals Tactical Strike | 11.06.2007 | Sony Computer Entertainment | PSP |
| SOCOM US Navy Seals Tactical Strike - Used | | GameStop.com | PSP |
| Sonic Rivals | | | PSP |
| Sonic Rivals | 11.16.2006 | Sega of America | PSP |
| Sonic Rivals 2 | 11.13.2007 | Sega of America | PSP |
| Space Invaders Extreme | 06.17.2008 | Square Enix | PSP |
| Space Invaders Extreme | 06.17.2008 | SquareEnix | PSP |
| Spectral Souls | 09.26.2006 | NIS America | PSP |
| Spectral Souls | | | PSP |
| Spider-Man 2 | | Sony Entertainment | PSP |
| Spider-Man 2 | 03.21.2005 | Activision | PSP |
| Spider-Man New Animated Series | | Sony Entertainment | PSP |
| Spider-Man: Friend or Foe | 10.02.2007 | Activision | PSP |
| Splinter Cell: Double Agent | 03.21.2006 | Ubi Soft | PSP |
| Sponge Bob Square Pants: Yellow Ave | 03.06.2006 | THQ | PSP |
| SSX On Tour | | Electronic Arts | PSP |
| Stacked | 10.03.2006 | Myelin Media LLC | PSP |
| Star Trek: Tactical Assault | 11.14.2006 | Bethesda Softworks | PSP |
| Star Wars Battlefront II | 11.01.2005 | Lucasarts Entertainment | PSP |
| Star Wars Battlefront: Renegade Squadron | 10.09.2007 | Lucasarts Entertainment | PSP |
| Star Wars The Force Unleashed | 09.01.2008 | LucasArts Entertainment Company | PSP |
| Star Wars: Lethal Alliance | 12.05.2006 | Ubi Soft | PSP |
| Starship Troopers | | Sony | PSP |
| Steel Horizon | 07.03.2007 | Konami | PSP |
| Street Fighter Alpha 3 MAX | 02.07.2006 | Capcom | PSP |
| Street Supremacy | 02.28.2006 | Konami | PSP |
| Sudoku | 03.21.2006 | Ubi Soft | PSP |
| Super Monkey Ball Adventure | 08.29.2006 | Sega | PSP |
| Superman Returns | 11.20.2006 | Electronic Arts | PSP |
| Surf's Up | 05.29.2007 | Ubi Soft | PSP |
| SWAT: Target Liberty | 10.16.2007 | Sierra | PSP |
| Syphon Filter: Dark Mirror | 03.14.2006 | Sony Computer Entertainment | PSP |
| Syphon Filter: Logan's Shadow | 10.02.2007 | Sony Computer Entertainment | PSP |