INTEL's latest microchip technology has created transistors 22 nanometres wide - a mere 200 times the width of a hydrogen molecule. Carving such tiny features is devilishly difficult and expensive, but in another realm of microchips altogether, something odd is happening: chips are being made on an outsized scale and then shrunk to the required size, avoiding much fiddly hassle.
The shrinking innovation is happening in the field of the "lab-on-a-chip". Such chips are typically plastic slivers scored with serried ranks of fluid-filled microchannels and recessed pools for chemical reactions to occur in; they are often replete with deposits of chemicals, cells and proteins of interest.
The idea? To provide a swift diagnostic tool: add some body fluids and let the gadget look for telltale chemical changes that reveal biomarkers linked to various diseases. One day, a handheld gadget may scan you for a multitude of ailments.
But there's a problem, says biochemical engineer Christophe Marquette and colleagues at the Claude Bernard University in Lyon, France. Microfluidic chips are hard to manufacture and are consequently too expensive for throwaway systems. What's more, the difficulty of making them so tiny constrains the creativity of their designers.
The Lyon team's answer is simple but powerful: carve and print the features on a large chip made of PolyShrink, a heat-shrinkable polymer, which is then warmed.
So far they have shrunk a 230-micrometre-square biochip down to 100-micrometres square. Of course, the material does not disappear as it shrinks - instead it gets thicker, moving from 15 to 85 micrometres thick.
Crucially, its features remained in good shape. In tests, the chip's reaction chambers, drug reservoirs, channels and patterns of cells shrunk uniformly, maintaining the same relative dimensions right down to the final chip size (Lab On A Chip, DOI: 10.1039/b913253h). Even complex spiral-shaped channels were faithfully reproduced.
Marquette says this "print 'n' shrink" technology could give designers of such chips more room to manoeuvre, as well as allowing for greater precision in their manufacture.
'Print 'n' shrink' technology could give the designers of diagnostic biochips greater freedom
"This development sounds potentially useful and could reduce the cost of fabrication in the microfluidics field," says Jon Cooper, a bioengineer at the University of Glasgow in the UK.
- Subscribe to New Scientist and you'll get:
- 51 issues of New Scientist magazine
- Unlimited access to all New Scientist online content -
a benefit only available to subscribers - Great savings from the normal price
- Subscribe now!
If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.
Have your say
Hmmmmm!
Nothing new but I knew the had to be a reason my fish and chip portions are getting smaller.
Seriously the applications are massive but if it is out in the open now the military have be applying this to more sinister uses for many years.
Nano chips in the water supply anyone?
Labs-on-a-chip That You Can Shrink To Fit
Sun Oct 18 00:10:46 BST 2009 by Dennis
http://freetubetv.net
You do realize that a good deal of research comes from the military or from the sheer tinkering around of household products for military applications. The internet and the jeep (4x4 steering) are just examples of that.
I read about a researcher named Michelle Khine who came up with the idea of using Shrinky Dinks and a laser printer to produce shinkable bio-chips.
http://www.technologyreview.com/tr35/Profile.aspx?TRID=764
Surprised she wasn't mentioned.... Wonder who really had the idea first.....
This Sounds Like Michelle Khine's Work. . .
Sat Oct 17 20:19:50 BST 2009 by Paul Marks
http://twitter.com/pau1m
(I wrote this story.)
You're almost right. But Michelle Khine's group did not make a chip and then shrink it. They made pieces the right shape and shrunk them to make moulds for biochips. So the shrunken parts would produce the right shape reactor or channel when impressed in a substrate. This group has made the whole chip and shrunk it.
I aproached Khine's company, Nanoshrink, for comment on this but they did not reply by deadline. Hoping to hear from them next week - so there may be an update.
Khine did molds, direct chips, metalized chips and even multi-layer chips.
The new group's innovation is printing proteins on the substrate before shrinking.
"Microfluidic chips are hard to manufacture and are consequently too expensive for throwaway systems. What's more, the difficulty of making them so tiny constrains the creativity of their designers."
I disagree. Aren't most, if not all, microfluidic devices 'throwaway' (single-use)? Also, it's possible to standardise chips to make them relatively cheap. (See 'Programmable Micofluidics' [sic] at http://www.youtube.com/watch?v=n0gmTc2wA3k)
Cheap At Twice The Price
Sat Oct 17 21:57:43 BST 2009 by Joe
http://www.youtube.com/watch?v=n0gmTc2wA3k
Hrmph.. Please remove the parenthesis from my previous link, or use the one above.
All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.
If you are having a technical problem posting a comment, please contact technical support.