Common cold

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Common cold
Classification and external resources

Molecular surface of one variant of human rhinovirus.
ICD-10 J00.0
ICD-9 460
DiseasesDB 31088
MedlinePlus 000678
eMedicine aaem/118 med/2339
MeSH D003139

The common cold (viral upper respiratory tract infection (VURI), acute viral rhinopharyngitis, acute coryza, or cold) is a contagious, viral infectious disease of the upper respiratory system, caused primarily by rhinoviruses and coronaviruses. Common symptoms include a sore throat, runny nose, and fever. There is no cure, however symptoms usually resolves spontaneously in 7 to 10 days, with some symptoms possibly lasting for up to three weeks.[1]

The common cold is the most frequent infectious disease in humans[2] with on average two to four infections a year in adults and up to 6 - 12 in children. Collectively, colds, influenza, and other infections with similar symptoms are included in the diagnosis of influenza-like illness. They may also be termed upper respiratory tract infections (URTI). Influenza involves the lungs while the common cold does not.

Contents

Signs and symptoms

Symptoms are cough, sore throat, runny nose, and nasal congestion; sometimes this may be accompanied by conjunctivitis ( pink eye ), muscle aches, fatigue, headaches, shivering, and loss of appetite. Fever is often present thus creating a symptom picture which overlaps with influenza.[3] The symptoms of influenza howerver are usually more severe.[4] The common cold usually resolves spontaneously in 7 to 10 days, but some symptoms can last for up to three weeks.[1] In children the cough lasts for more than 10 days in 35-40% and continue for more than 25 days in 10%.[5]

Those suffering from colds often report a sensation of chilliness even though the cold is not generally accompanied by fever, and although chills are generally associated with fever, the sensation may not always be caused by actual fever.[3] In one study, 60% of those suffering from a sore throat and upper respiratory tract infection reported headaches[3], often due to nasal congestion.

Progression

The viral replication begins 8 to 12 hours after initial contact.[6] Symptoms usually begin 2 to 5 days after initial infection but occasionally occur in as little as 10 hours.[7] Symptoms peak 2–3 days after symptom onset, whereas influenza symptom onset is constant and immediate.[3] The symptoms usually resolve spontaneously in 7 to 10 days but some can last for up to three weeks.[1]

The first indication of an upper respiratory virus is often a sore or scratchy throat. Other common symptoms are runny nose, congestion, and sneezing.[8] These are sometimes accompanied by muscle aches, fatigue, malaise, headache, weakness, or loss of appetite.[9] Cough and fever generally indicate influenza rather than an upper respiratory virus with a positive predictive value of around 80%.[3] Symptoms may be more severe in infants and young children, and in these cases it may include fever and hives.[10] Upper respiratory viruses may also be more severe in smokers.[11]

Complications

The common cold can lead to symptoms of acute bronchitis, bronchiolitis, croup, pneumonia, sinusitis, otitis media, or strep throat. People with chronic lung diseases such as asthma and COPD are especially vulnerable. Colds may cause acute exacerbations of asthma, emphysema or chronic bronchitis.[6]

Cause

Viruses

The common cold is due to a viral infection of the upper respiratory track. The most common implicated is rhinovirus (30-50%), a type of picornavirus with 99 known serotypes.[12][13][3] Others include: coronavirus (10-15%), influenza (5-15%)[3], human parainfluenza viruses, human respiratory syncytial virus, adenoviruses, enteroviruses, and metapneumovirus.[8]

In total over 200 serologically different viral types cause colds.[3] Coronaviruses are particularly implicated in adult colds. Of over 30 coronaviruses, 3 or 4 cause infections in humans, but they are difficult to grow in the laboratory and their significance is thus less well-understood.[8] Due to the many different types of viruses and their tendency for continuous mutation, it is impossible to gain complete immunity to the common cold.

Risk factors

  • A tendency to touch your eyes or nose. If you touch your eyes or nose frequently, you are increasing the likelihood of transferring viruses from your hands into your upper respiratory tract.[14][15]
  • Not keeping your hands clean.[14][15] Cleaning hands with soap and water, or with an alcohol-based hand sanitizer, has many benefits. First, it helps to reduce (although it does not eliminate) the chance of transferring the virus to your eyes or nose if you DO accidentally touch them. Second, cleaning your hands helps to reduce the spread of viruses from surface to surface, thereby reducing the number of "danger points" for both you and the people around you. And anything you can do to help keep others from getting colds will help to break the viruses' chain of transmission, thereby ultimately perhaps keeping you healthy as well.
  • A history of smoking extends the duration of illness about three days.[16]
  • A lack of sleep has been associated with those who sleep fewer than 7 hours per night three times more likely to develop an infection when exposed to a rhinovirus than those who sleep more than 8 hours per night.[17]
  • Low blood vitamin D levels are associated with an increased the risk of getting a common cold.[18] Whether this relation is causal is yet to be determined.[19]
  • Common colds are seasonal, occurring more frequently during winter. This is believed to be due to a behaviors changes such as increased time spent indoors at close proximity to others rather exposure to cold temperatures.[8][20].
  • Humidity may play a role in viral transmission. One theory is that dry air causes evaporation of water thus allowing small viral droplets to disperse farther and stay in the air longer. [21]

Pathophysiology

The common cold is a disease of the upper respiratory tract

The common cold virus is transmitted mainly from contact with the saliva or nasal secretions of an infected person, either directly, when a healthy person breathes in the virus-laden aerosol generated when an infected person coughs or sneezes, or by touching a contaminated surface and then touching the nose or eyes.[22]

Symptoms are not necessary for viral shedding or transmission, as a percentage of asymptomatic subjects exhibit viruses in nasal swabs.[23] It is generally not possible to identify the virus type through symptoms, although influenza can be distinguished by its sudden onset, fever, and cough.[3]

The major entry point for the virus is normally the nose, but can also be the eyes (in this case drainage into the nasopharynx would occur through the nasolacrimal duct). From there, it is transported to the back of the nose and the adenoid area. The virus then attaches to a receptor, ICAM-1, which is located on the surface of cells of the lining of the nasopharynx. The receptor fits into a docking port on the surface of the virus. Large amounts of virus receptor are present on cells of the adenoid. After attachment to the receptor, virus is taken into the cell, where it starts an infection.[6] Rhinovirus colds do not generally cause damage to the nasal epithelium. Macrophages trigger the production of cytokines, which in combination with mediators cause the symptoms. Cytokines cause the systemic effects. The mediator bradykinin plays a major role in causing the local symptoms such as sore throat and nasal irritation.[3]

The common cold is self-limiting, and the host's immune system effectively deals with the infection. Within a few days, the body's humoral immune response begins producing specific antibodies that can prevent the virus from infecting cells. Additionally, as part of the cell-mediated immune response, leukocytes destroy the virus through phagocytosis and destroy infected cells to prevent further viral replication. In healthy, immunocompetent individuals, the common cold resolves in seven days on average.[6]

Prevention

The best prevention is thorough and regular washing of the hands.[24] This results in a 16% decrease in the rate of respiratory infections[25] and as much as a 20% decrease in the common cold.[26] Anti-bacterial and non anti-bacterial soaps are equally effective.[24] Alcohol-based hand sanitizers also reduce viruses significantly[27] and are recommended as a method in health care environments.[28] The use of alcohol based hand gels in the home reduces rate of transmission of respiratory illnesses among family members.[29]

Another important prevention measure is to avoid touching your nose and eyes.[14][15] That may not reduce the spread of the virus in the environment, but it is the last line of defence against picking up viruses from contaminated surfaces and allowing them entrance into your upper respiratory tract where they can cause infection.

Developing a vaccine for the common cold has been unsuccessful. This is due to a number of reasons including: a large variety of viruses and the fact that these viruses mutate rapidly. Many thus believe that successful immunization is highly improbable.[30] Probiotics in children 3 – 5 years old were found effective in decreases cold symptoms when taken over 6 months.[31]

Management

Poster encouraging citizens to "Consult your Physician" for treatment of the common cold

There are currently no medications or herbal remedies which have been conclusively demonstrated to shorten the duration of illness.[32] Treatment comprises symptomatic support usually via analgesics for fever, headache, sore muscles, and sore throat.

Conservative

Treatments that help alleviate symptoms include simple analgesics and antipyretics such as ibuprofen[33] and acetaminophen / paracetamol. Evidence does not show that cold medicines are any more effective than simple analgesics[34] and are not recommended for use in children due to no evidence supporting their effectiveness and the potential of harm.[35][36]

Getting plenty of rest, drinking fluids to maintain hydration, and gargling with warm salt water, are reasonable conservative measures.[8] Evidence for encouraging the active intake of fluids in acute respiratory infections is lacking[37] as is the use of heated humidified air.[38] Saline nasal drops may help alleviate nasal congestion.[39]

Antibiotics and antivirals

Antibiotics are not effective against the viruses that causes the common cold[40] and due to their side effects cause overall harm.[40] There are no approved antiviral drugs for the common cold even though some preliminary research has shown benefit.[41]

Alternative treatments

Main article: Alternative treatments used for the common cold

Many alternative treatments are used to treat the common cold. However, there is insufficient scientific evidence to support the use of any alternative medicine treatments.[11][42] Honey may be an effective treatment of cough and improved sleep difficulty in children more than no treatment or dextromethorphan.[43]

Prognosis

The common cold is generally mild and self-limiting.[44]

Epidemiology

Upper respiratory tract infections are the most common infectious diseases among adults, who have two to four respiratory infections annually.[45] Children may have six to ten colds a year (and up to 12 colds a year for school children).[8][46] In the United States, the incidence of colds is higher in the fall (autumn) and winter, with most infections occurring between September and April. The seasonality may be due to the start of the school year, or due to people spending more time indoors (thus in closer proximity with each other) increasing the chance of transmission of the virus.[8]

History

"Definition of a Cold." Benjamin Franklin's notes for a paper he intended to write on the common cold.

The name "common cold" came into use in the 16th century, due to the similarity between its symptoms and those of exposure to cold weather.[47] Norman Moore relates in his history of the Study of Medicine that James I continually suffered from nasal colds, which were then thought to be caused by polypi, sinus trouble, or autotoxaemia.[48]

In the 18th century, Benjamin Franklin considered the causes and prevention of the common cold. After several years of research he concluded: "People often catch cold from one another when shut up together in small close rooms, coaches, etc. and when sitting near and conversing so as to breathe in each other's transpiration." Although viruses had not yet been discovered, Franklin hypothesized that the common cold was passed between people through the air. He recommended exercise, bathing, and moderation in food and drink consumption to avoid the common cold.[49] Franklin's theory on the transmission of the cold was confirmed some 150 years later.[50]

Common Cold Unit

Main article: Common Cold Unit

In the United Kingdom, the Common Cold Unit was set up by the Medical Research Council in 1946. The unit worked with volunteers who were infected with various viruses.[51] The rhinovirus was discovered there.[52] In the late 1950s, researchers were able to grow one of these cold viruses in a tissue culture, as it would not grow in fertilized chicken eggs, the method used for many other viruses. In the 1970s, the CCU demonstrated that treatment with interferon during the incubation phase of rhinovirus infection protects somewhat against the disease[53], but no practical treatment could be developed. The unit was closed in 1989, two years after it completed research of zinc gluconate lozenges in the prophylaxis and treatment of rhinovirus colds, the only successful treatment in the history of the unit.[54]

Social and cultural

Economics

A British poster from World War II describing the cost of the common cold[55]
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 The examples and perspective in this article deal primarily with the United States and do not represent a worldwide view of the subject. Please improve this article and discuss the issue on the talk page.

In the United States, the common cold leads to 75 to 100 million physician visits annually at a conservative cost estimate of $7.7 billion per year. Americans spend $2.9 billion on over-the-counter drugs and another $400 million on prescription medicines for symptomatic relief.[45][56]

More than one-third of patients who saw a doctor received an antibiotic prescription, which has implications for antibiotic resistance from overuse of such drugs.[56]

An estimated 22 to 189 million school days are missed annually due to a cold. As a result, parents missed 126 million workdays to stay home to care for their children. When added to the 150 million workdays missed by employees suffering from a cold, the total economic impact of cold-related work loss exceeds $20 billion per year.[8][45][56] This accounts for 40% of time lost from work.[57]

Legal

Canada in 2009 restricted the use of over-the-counter cough and cold medication in children 6 years and under due to concerns regarding risks and unproven benefits.[36]

Cold weather

An ancient belief still common today claims that a cold can be "caught" by prolonged exposure to cold weather such as rain or winter conditions, which is where the disease got its name.[58] Although common colds are seasonal, with more occurring during winter, experiments so far have failed to produce evidence that short-term exposure to cold weather or direct chilling increases susceptibility to infection, implying that the seasonal variation is instead due to a change in behaviors such as increased time spent indoors at close proximity to others.[8][20]

Research

Biota Holdings are developing a drug, currently known as BTA798, which targets rhinovirus. The drug has recently successfully completed Phase IIa clinical trials.[59][60]

ViroPharma and Schering-Plough are developing an antiviral drug, pleconaril, that targets picornaviruses, the viruses that cause the majority of common colds. Pleconaril has been shown to be effective in an oral form.[61][62] Schering-Plough is developing an intra-nasal formulation that may have fewer adverse effects.[63]

Researchers from University of Maryland, College Park and University of Wisconsin–Madison have mapped the genome for all known virus strains that cause the common cold.[63]

References

  1. ^ a b c Heikkinen T, Järvinen A (January 2003). "The common cold". Lancet 361 (9351): 51–9. doi:10.1016/S0140-6736(03)12162-9. PMID 12517470. 
  2. ^ Macnair, Dr. Trisha. "The Common Cold". bbc.co.uk Health. BBC. http://www.bbc.co.uk/health/conditions/commoncold.shtml. Retrieved 30 September 2009. 
  3. ^ a b c d e f g h i j Eccles R (November 2005). "Understanding the symptoms of the common cold and influenza". Lancet Infect Dis 5 (11): 718–25. doi:10.1016/S1473-3099(05)70270-X. PMID 16253889. 
  4. ^ Nordenberg, Tamar (May 1999). "Colds and Flu: Time Only Sure Cure". Food and Drug Administration. http://www.fda.gov/fdac/features/896_flu.html. Retrieved 13 June 2007. 
  5. ^ Goldsobel AB, Chipps BE (March 2010). "Cough in the pediatric population". J. Pediatr. 156 (3): 352–358.e1. doi:10.1016/j.jpeds.2009.12.004. PMID 20176183. 
  6. ^ a b c d Gwaltney, JM, Hayden, FG (2006). "Understanding Colds". http://www.commoncold.org/index.htm. Retrieved 3 July 2007. 
  7. ^ Patsy Hamilton. "Facts about the Common Cold Incubation Period". http://www.healthguidance.org/entry/6125/1/Facts-about-the-Common-Cold-Incubation-Period.html. Retrieved 3 July 2007. 
  8. ^ a b c d e f g h i "Common Cold". National Institute of Allergy and Infectious Diseases. 27 November 2006. http://www3.niaid.nih.gov/healthscience/healthtopics/colds/. Retrieved 11 June 2007. 
  9. ^ "Common Cold Centre". Cardiff University. 2006. http://www.cardiff.ac.uk/biosi/subsites/cold/commoncold.html. Retrieved 6 September 2007. 
  10. ^ "Colds in children". Canadian Pediatric Society. October 2005. http://www.cps.ca/caringforkids/whensick/colds.htm. Retrieved 16 July 2007. 
  11. ^ a b "A Survival Guide for Preventing and Treating Influenza and the Common Cold". American Lung Association. August 2005. http://www.lungusa.org/site/pp.asp?c=dvLUK9O0E&b=35873#done. Retrieved 11 June 2007. 
  12. ^ Mary Engel (February 13, 2009). "Rhinovirus strains' genomes decoded; cold cure-all is unlikely: The strains are probably too different for a single treatment or vaccine to apply to all varieties, scientists say". Los Angeles Times. http://www.latimes.com/news/science/la-sci-cold13-2009feb13,0,6469591.story. 
  13. ^ Palmenberg, A. C.; Spiro, D; Kuzmickas, R; Wang, S; Djikeng, A; Rathe, JA; Fraser-Liggett, CM; Liggett, SB (2009). "Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveals Structure and Evolution". Science 324 (5923): 55. doi:10.1126/science.1165557. PMID 19213880. 
  14. ^ a b c "NIAID > Topics > Common Cold". http://www3.niaid.nih.gov/topics/commonCold/prevention.htm. Retrieved Mar01, 2010. 
  15. ^ a b c "Error: no |title= specified when using {{Cite web}}". http://commoncold.org/prevent1.htm. Retrieved Mar01, 2010. 
  16. ^ Aronson MD, Weiss ST, Ben RL, Komaroff AL (July 1982). "Association between cigarette smoking and acute respiratory tract illness in young adults". JAMA 248 (2): 181–3. PMID 7087108. 
  17. ^ Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB (January 2009). "Sleep habits and susceptibility to the common cold". Arch. Intern. Med. 169 (1): 62–7. doi:10.1001/archinternmed.2008.505. PMID 19139325. 
  18. ^ Ginde AA, Mansbach JM, Camargo CA (February 2009). "Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey". Arch. Intern. Med. 169 (4): 384–90. doi:10.1001/archinternmed.2008.560. PMID 19237723. 
  19. ^ "Sunshine Vitamin Diminishes Risk Of Colds, Flu - Science News". Science News. http://www.sciencenews.org/view/generic/id/41121/title/Sunshine_vitamin_diminishes_risk_of_colds,_flu. Retrieved Dec 16,2009. 
  20. ^ a b Eccles R (2002). "Acute cooling of the body surface and the common cold". Rhinology 40 (3): 109–14. PMID 12357708. 
  21. ^ "Absolute humidity modulates influenza survival, transmission, and seasonality". Science News. http://www.pnas.org/content/early/2009/02/09/0806852106.abstract. Retrieved Jan21, 2010. 
  22. ^ Gina Kolata (December 5, 2007). "Study Shows Why the Flu Likes Winter". New York Times. http://www.nytimes.com/2007/12/05/health/research/05flu.html. 
  23. ^ "Common Cold" (PDF). Department of Health, Government of South Australia. 2005. http://dh.sa.gov.au/pehs/Youve-got-what/ygw-common-cold.pdf. Retrieved 20 June 2007. 
  24. ^ a b "Staying healthy is in your hands - Public Health Agency Canada". 17 April 2008. http://www.phac-aspc.gc.ca/chn-rcs/handwash-eng.php. Retrieved 5 May 2008. 
  25. ^ Rabie T, Curtis V (March 2006). "Handwashing and risk of respiratory infections: a quantitative systematic review". Trop. Med. Int. Health 11 (3): 258–67. doi:10.1111/j.1365-3156.2006.01568.x. PMID 16553905. 
  26. ^ Jefferson T, Del Mar C, Dooley L, et al. (2009). "Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review". BMJ 339: b3675. PMID 19773323. 
  27. ^ S. Bloomfield (2007). "The effectiveness of hand hygiene procedures in reducing the risks of infections in home and community settings including handwashing and alcohol-based hand sanitizers". American Journal of Infection Control 35 (10): S27-S64. 
  28. ^ Boyce JM, Pittet D (October 2002). "Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America". MMWR Recomm Rep 51 (RR-16): 1–45, quiz CE1–4. PMID 12418624. 
  29. ^ Lee GM, Salomon JA, Friedman JF, et al. (April 2005). "Illness transmission in the home: a possible role for alcohol-based hand gels". Pediatrics 115 (4): 852–60. doi:10.1542/peds.2004-0856. PMID 15805355. 
  30. ^ "Gene studies shed light on rhinovirus diversity.". http://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2809%2970123-9. 
  31. ^ Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC (August 2009). "Probiotic effects on cold and influenza-like symptom incidence and duration in children". Pediatrics 124 (2): e172–9. doi:10.1542/peds.2008-2666. PMID 19651563. 
  32. ^ "Common Cold: Treatments and Drugs". Mayo Clinic. http://www.mayoclinic.com/health/common-cold/DS00056/DSECTION=treatments-and-drugs. Retrieved 09 January 2010. 
  33. ^ Kim SY, Chang YJ, Cho HM, Hwang YW, Moon YS (2009). "Non-steroidal anti-inflammatory drugs for the common cold". Cochrane Database Syst Rev (3): CD006362. doi:10.1002/14651858.CD006362.pub2. PMID 19588387. 
  34. ^ Smith SM, Schroeder K, Fahey T (2008). "Over-the-counter medications for acute cough in children and adults in ambulatory settings". Cochrane Database Syst Rev (1): CD001831. doi:10.1002/14651858.CD001831.pub3. PMID 18253996. 
  35. ^ "UpToDate Inc.". http://www.uptodate.com/online/content/topic.do?topicKey=pedi_id/16291&selectedTitle=1~116&source=search_result#20. 
  36. ^ a b "Use of over-the-counter cough and cold medications in children -- Shefrin and Goldman 55 (11): 1081 -- Canadian Family Physician". http://www.cfp.ca/cgi/content/abstract/55/11/1081?etoc. 
  37. ^ Guppy MP, Mickan SM, Del Mar CB (2005). "Advising patients to increase fluid intake for treating acute respiratory infections". Cochrane Database Syst Rev (4): CD004419. doi:10.1002/14651858.CD004419.pub2. PMID 16235362. 
  38. ^ Singh M (2006). "Heated, humidified air for the common cold". Cochrane Database Syst Rev 3: CD001728. doi:10.1002/14651858.CD001728.pub3. PMID 16855975. 
  39. ^ "Common Cold". PDRHealth. Thomson Healthcare. http://www.pdrhealth.com/disease/disease-mono.aspx?contentFileName=BHG01ID25.xml&contentName=Common+Cold&contentId=30. Retrieved 11 July 2007. 
  40. ^ a b Arroll B, Kenealy T (2005). "Antibiotics for the common cold and acute purulent rhinitis". Cochrane Database Syst Rev (3): CD000247. doi:10.1002/14651858.CD000247.pub2. PMID 16034850. 
  41. ^ Gwaltney JM, Winther B, Patrie JT, Hendley JO (July 2002). "Combined antiviral-antimediator treatment for the common cold". J. Infect. Dis. 186 (2): 147–54. doi:10.1086/341455. PMID 12134249. 
  42. ^ Simasek M, Blandino DA (February 2007). "Treatment of the common cold". Am Fam Physician 75 (4): 515–20. PMID 17323712. 
  43. ^ "Honey A Better Option For Childhood Cough Than Over The Counter Medications". 2007-12-04. http://www.sciencedaily.com/releases/2007/12/071203164750.htm. Retrieved 2009-11-27. 
  44. ^ "Upper Respiratory Tract Infection: eMedicine Pulmonology". http://emedicine.medscape.com/article/302460-overview. 
  45. ^ a b c Garibaldi RA (1985). "Epidemiology of community-acquired respiratory tract infections in adults. Incidence, etiology, and impact". Am. J. Med. 78 (6B): 32–7. doi:10.1016/0002-9343(85)90361-4. PMID 4014285. 
  46. ^ Simasek M, Blandino DA (2007). "Treatment of the common cold". American family physician 75 (4): 515–20. PMID 17323712. http://www.aafp.org/afp/20070215/515.html. 
  47. ^ "Cold". Online Etymology Dictionary. http://www.etymonline.com/index.php?term=cold. Retrieved 12 January 2008. 
  48. ^ Wylie, A, (1927). "Rhinology and laryngology in literature and Folk-Lore". The Journal of Laryngology & Otology 42 (2): 81–87. doi:10.1017/S0022215100029959. 
  49. ^ "Scientist and Inventor: Benjamin Franklin: In His Own Words... (AmericanTreasures of the Library of Congress)". http://www.loc.gov/exhibits/treasures/franklin-scientist.html. Retrieved 23 December 2007. 
  50. ^ Andrewes CH, Lovelock JE, Sommerville T (1951). "An experiment on the transmission of colds". Lancet 1 (1): 25–7. doi:10.1016/S0140-6736(51)93497-6. PMID 14795755. 
  51. ^ Reto U. Schneider (2004). Das Buch der verrückten Experimente (Broschiert). München: Goldmann. ISBN 344215393X. http://www.verrueckte-experimente.de/index_e.html. 
  52. ^ Tyrrell DA (1988). "Hot news on the common cold". Annu. Rev. Microbiol. 42: 35–47. doi:10.1146/annurev.mi.42.100188.000343. PMID 2849371. 
  53. ^ Tyrrell DA (1987). "Interferons and their clinical value". Rev. Infect. Dis. 9 (2): 243–9. PMID 2438740. 
  54. ^ Al-Nakib, W; Higgins, PG; Barrow, I; Batstone, G; Tyrrell, DA (December 1987). "Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges". J Antimicrob Chemother. 20 (6): 893–901. doi:10.1093/jac/20.6.893. PMID 3440773. 
  55. ^ http://vads.bath.ac.uk/flarge.php?uid=33443&sos=0
  56. ^ a b c Fendrick AM, Monto AS, Nightengale B, Sarnes M (2003). "The economic burden of non-influenza-related viral respiratory tract infection in the United States". Arch. Intern. Med. 163 (4): 487–94. doi:10.1001/archinte.163.4.487. PMID 12588210. http://archinte.ama-assn.org/cgi/content/full/163/4/487. 
  57. ^ Kirkpatrick GL (December 1996). "The common cold". Prim. Care 23 (4): 657–75. PMID 8890137. 
  58. ^ Zuger, Abigail 'You'll Catch Your Death!' An Old Wives' Tale? Well . . . The New York Times (March 4, 2003). Retrieved on 12-17-08.
  59. ^ "The new pill that could signal the death of the common cold". August 2008. http://www.dailymail.co.uk/health/article-1043719/The-new-pill-signal-death-common-cold.html. Retrieved 19 August 2009. 
  60. ^ "Biota Press Release". June 2009. http://www.biota.com.au/uploaded/154/1021521_38hrvphaseiiastudyachieve.pdf. Retrieved 19 August 2009. 
  61. ^ Pevear, Daniel C.; T; S; G (1 September 1999). "Activity of Pleconaril against Enteroviruses". Antimicrobial Agents and Chemotherapy 43 (9): 2109–2115. PMID 10471549. http://aac.asm.org/cgi/content/full/43/9/2109. 
  62. ^ McConnell, J. (2 October 1999). "Enteroviruses succumb to new drug". The Lancet 354 (9185): 1185. doi:10.1016/S0140-6736(05)75393-9. 
  63. ^ a b "Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus Exposure (Study P04295AM2)". ClinicalTrials.gov. U.S. National Institutes of Health. March 2007. http://www.clinicaltrials.gov/ct/gui/show/NCT00394914. Retrieved 10 April 2007. 

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