Bisphenol A

From Wikipedia, the free encyclopedia

Jump to: navigation, search
Bisphenol A
IUPAC name
4,4'-dihydroxy-2,2-diphenylpropane
Other names
BPA, 4,4'-(propan-2-ylidene)diphenol,
p, p'-isopropylidenebisphenol,
4,4´-isopropylidenediphenol,
2,2-bis(4-hydroxyphenyl)propane.
Identifiers
CAS number 80-05-7 YesY
PubChem 6623
ChemSpider 6371
EC number 201-245-8
RTECS number SL6300000
SMILES
InChI
InChI key IISBACLAFKSPIT-UHFFFAOYAI
Properties
Molecular formula C15H16O2
Molar mass 228.29 g mol−1
Appearance White to light brown flakes or powder
Density 1.20 g/cm³, solid
Melting point

158 to 159 °C (430 K)
Boiling point

220 °C (493 K) / 4 mmHg
Solubility in water 120–300 ppm (at 21.5 °C)
Hazards
R-phrases R36, R37, R38, R43
S-phrases S24, S26, S37
NFPA 704
NFPA 704.svg
0
3
0
Flash point 227°C
Related compounds
Related compounds phenols
Bisphenol S
 YesY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Bisphenol A, commonly abbreviated as BPA, is an organic compound with two phenol functional groups. It is a difunctional building block of several important plastics and plastic additives.

Suspected of being hazardous to humans since the 1930s, concerns about the use of bisphenol A in consumer products were regularly reported in the news media in 2008 after several governments issued reports questioning its safety, thus prompting some retailers to remove products containing it from their shelves. A 2010 report from the United States Food and Drug Administration (FDA) raised further concerns regarding exposure of fetuses, infants, and young children.[1]

Contents

[edit] Synthesis

Bisphenol A was first reported by A.P. Dianin in 1891.[2][3]

It is prepared by the condensation of acetone (hence the suffix A in the name)[4] with two equivalents of phenol. The reaction is catalyzed by an acid, such as hydrochloric acid (HCl) or a sulfonated polystyrene resin. Typically, a large excess of phenol is used to ensure full condensation:

(CH3)2CO + 2 C6H5OH → (CH3)2C(C6H4OH)2 + H2O

A large number of ketones undergo analogous condensation reactions. Commercial production of BPA requires distillation - either extraction of BPA from many resinous byproducts under high vacuum, or solvent-based extraction using additional phenol followed by distillation.[5]

[edit] Use

Further information: Polycarbonate
Repeating chemical structure unit of polycarbonate made from bisphenol A

Bisphenol A is used primarily to make plastics, and products containing bisphenol A-based plastics have been in commerce for more than 50 years. It is a key monomer in production of epoxy resins[6][7] and in the most common form of polycarbonate plastic.[5][8][9] Polycarbonate plastic, which is clear and nearly shatter-proof, is used to make a variety of common products including baby and water bottles, sports equipment, medical and dental devices, dental fillings and sealants, eyeglass lenses, CDs and DVDs, and household electronics.[10] BPA is also used in the synthesis of polysulfones and polyether ketones, as an antioxidant in some plasticizers, and as a polymerization inhibitor in PVC. Epoxy resins containing bisphenol A are used as coatings on the inside of almost all food and beverage cans,[11] however, due to BPA health concerns, in Japan epoxy coating was mostly replaced by PET film.[12] Bisphenol A is also a precursor to the flame retardant tetrabromobisphenol A, and was formerly used as a fungicide.[13] Bisphenol A is a preferred color developer in thermal paper[14] and in carbonless copy paper.[15] BPA-based products are also used in foundry castings and for lining water pipes.[16]

Global production of bisphenol A in 2003 was estimated to be over 2 million tonnes.[17] In the U.S., it is manufactured by Bayer MaterialScience, Dow Chemical Company, SABIC Innovative Plastics (formerly GE Plastics), Hexion Specialty Chemicals, and Sunoco Chemicals. In 2004, these companies produced just over 1 million t of bisphenol A, up from just 7,260 t in 1991. In 2003, annual U.S. consumption was 856,000 t, 72% of which was used to make polycarbonate plastic and 21% going into epoxy resins.[10] In the US less than 5% of the BPA produced is used in food contact applications[16]

[edit] Identification in plastics

Main article: Resin identification code
Some type 7 plastics may leak bisphenol A
Flexible type 3 plastics may leak bisphenol A

There are seven classes of plastics used in packaging applications. Type 7 is the catch-all "other" class, and some type 7 plastics, such as polycarbonate (sometimes identified with the letters "PC" near the recycling symbol) and epoxy resins, are made from bisphenol A monomer.[5][18]

Type 3 (PVC) can also contain bisphenol A as an antioxidant in plasticizers.[5] This is particularly true for "flexible PVC", but not true for PVC pipes.

Types 1 (PET), 2 (HDPE), 4 (LDPE), 5 (polypropylene), and 6 (polystyrene) do not use bisphenol A during polymerization or package forming.[citation needed] [19]

[edit] Health effects

Bisphenol A is an endocrine disruptor, which can mimic the body's own hormones and may lead to negative health effects.[20][21][22][23] Early development appears to be the period of greatest sensitivity to its effects.[24] Regulatory bodies have determined safety levels for humans, but those safety levels are currently being questioned or under review as a result of new scientific studies.[25][26]

In 2009 the The Endocrine Society released a scientific statement expressing concern over current human exposure to BPA.[27]

[edit] Previous studies

In 2007, a consensus statement by 38 experts on bisphenol A concluded that average levels in people are above those that cause harm to many animals in laboratory experiments.[28] A panel convened by the U.S. National Institutes of Health determined that there was "some concern" about BPA's effects on fetal and infant brain development and behavior.[10] A 2008 report by the U.S. National Toxicology Program (NTP) later agreed with the panel, expressing "some concern for effects on the brain, behavior, and prostate gland in fetuses, infants, and children at current human exposures to bisphenol A," and "minimal concern for effects on the mammary gland and an earlier age for puberty for females in fetuses, infants, and children at current human exposures to bisphenol A." The NTP had "negligible concern that exposure of pregnant women to bisphenol A will result in fetal or neonatal mortality, birth defects, or reduced birth weight and growth in their offspring."[29]

[edit] Obesity

A 2008 review has concluded that obesity may be increased as a function of BPA exposure, which "merits concern among scientists and public health officials".[30] A 2009 review of available studies has concluded that "perinatal BPA exposure acts to exert persistent effects on body weight and adiposity".[31] Another 2009 review has concluded that "Eliminating exposures to (BPA) and improving nutrition during development offer the potential for reducing obesity and associated diseases".[32] Other reviews have come with similar conclusions.[33][34]

[edit] Neurological issues

A panel convened by the U.S. National Institutes of Health determined that there was "some concern" about BPA's effects on fetal and infant brain development and behavior.[10] A 2008 report by the U.S. National Toxicology Program (NTP) later agreed with the panel, expressing "some concern for effects on the brain".[29] In January 2010 the FDA expressed the same level of concern.

A 2007 review has concluded that BPA, like other xenoestrogens, should be considered as a player within the nervous system that can regulate or alter its functions through multiple pathways.[35] A 2007 review has concluded that low doses of BPA during development have persistent effects on brain structure, function and behavior in rats and mice.[36] A 2008 review concluded that low-dose BPA maternal exposure causes long-term consequences at the level of neurobehavioral development in mice.[37] A 2008 review has concluded that neonatal exposure to Bisphenol-A (BPA) can affect sexually dimorphic brain morphology and neuronal phenotypes in adulthood.[38] A 2008 review has concluded that BPA altered long-term potentiation in the hippocampus and even nanomolar dosage could induce significant effects on memory processes.[39] A 2009 review raised concerns about BPA effect on anteroventral periventricular nucleus.[40]

A 2008 study by the Yale School of Medicine demonstrated that adverse neurological effects occur in non-human primates regularly exposed to bisphenol A at levels equal to the United States Environmental Protection Agency's (EPA) maximum safe dose of 50 µg/kg/day.[41][42] This research found a connection between BPA and interference with brain cell connections vital to memory, learning and mood.

Highly controversial claims have been made that BPA could be involved in attention-deficit hyperactivity disorder (ADHD)[43][44][45]

A 2010 study with rats perinatally exposed to 40 microg/kg bw BPA has concluded that corticosterone and its actions in the brain are sensitive to the programming effects of BPA.[46]

[edit] Disruption of the dopaminergic system

A 2005 review concluded that prenatal and neonatal exposure to BPA in mice can potentiate the central dopaminergic systems, resulting in the supersensitivity to the drugs-of-abuse-induced reward effects and hyperlocomotion.[47]

A 2008 review has concluded that BPA, mimic estrogenic activity and impact various dopaminergic processes to enhance mesolimbic dopamine activity resulting in hyperactivity, attention deficits, and a heightened sensitivity to drugs of abuse.[48]

A 2009 study on rats has concluded that prenatal and neonatal exposure to low-dose BPA causes deficits in development at dorsolateral striatum via altering the function of dopaminergic receptors.[49] Another 2009 study has found associated changes in the dopaminergic system.[45]

[edit] Thyroid function

A 2007 review has concluded that bisphenol-A has been shown to bind to thyroid hormone receptor and perhaps have selective effects on its functions.[50]

A 2009 review about environmental chemicals and thyroid function, raised concerns about BPA effects on triiodothyronine and concluded that "available evidence suggests that governing agencies need to regulate the use of thyroid-disrupting chemicals, particularly as such uses relate exposures of pregnant women, neonates and small children to the agents".[51]

A 2009 review summarized BPA adverse effects on thyroid hormone action.[52]

[edit] Cancer research

According to the WHO's INFOSAN, "animal studies have not provided convincing evidence of risk of cancer from BPA exposure."[53]

Neither the U.S. Environmental Protection Agency[54] nor the International Agency for Research on Cancer[55] has evaluated bisphenol A for possible carcinogenic activity.

A 2010 review concluded that Bisphenol A may increase cancer risk.[56]

[edit] Breast cancer

Further information: Risk factors of breast cancer#Bisphenol A

A 2008 review has concluded that "perinatal exposure to (...) low doses of (..) BPA, alters breast development and increases breast cancer risk".[57] Another 2008 review concluded that " animal experiments and epidemiological data strengthen the hypothesis that foetal exposure to xenoestrogens may be an underlying cause of the increased incidence of breast cancer observed over the last 50 years".[58]

A 2009 in vitro study has concluded that BPA is able to induce neoplastic transformation in human breast epithelial cells.[59] Another 2009 study concluded that maternal oral exposure to low concentrations of BPA during lactation increases mammary carcinogenesis in a rodent model.[60]

A 2010 study with the mammary glands of the offspring of pregnant rats treated orally with 0, 25 or 250 µg BPA/kg body weight has found that key proteins involved in signaling pathways such as cellular proliferation were regulated at the protein level by BPA.[61]

A 2010 study has found that BPA may reduce sensitivity to chemotherapy treatment of specific tumors.[62]

[edit] Neuroblastoma

In vitro studies have suggested that BPA can promote the growth of neuroblastoma cells.[63][64] A 2010 in vitro study has concluded that BPA potently promote invasion and metastasis of neuroblastoma cells through overexpression of MMP-2 and MMP-9 as well as downregulation of TIMP2.[65]

[edit] Prostate development and cancer

A 1997 study in mice has found that neonatal BPA exposure of 2 μg/kg increased adult prostate weight.[66] A 2005 study in mice has found that neonatal BPA exposure at 10 μg/kg disrupted the development of the fetal mouse prostate.[67] A 2006 study in rats has shown that neonatal bisphenol A exposure at 10 μg/kg levels increases prostate gland susceptibility to adult-onset precancerous lesions and hormonal carcinogenesis.[68] A 2007 in vitro study has found that BPA within the range of concentrations currently measured in human serum is associated with permanently increase in prostate size.[69] A 2009 study has found that newborn rats exposed to a low-dose of BPA (10 µg/kg) increased prostate cancer susceptibility when adults.[70]

[edit] DNA methylation

Bisphenol A suppress DNA methylation (by increased hypomethylation)[71] which is linked to epigenetic changes.[72]

[edit] Reproductive system and sexual behavior research

A series of studies made in 2009 found:

A 2010 study with mice concluded that BPA exposure in utero leads to permanent DNA alterations in sensitivity to estrogen.[85]

[edit] General research

In 2009, at an Endocrine Society meeting new research reported data from animals experimentally treated with BPA.[86] Studies presented at the group's annual meeting show BPA can affect the hearts of women, can permanently damage the DNA of mice, and appear to be entering the human body from a variety of unknown sources.[87]

A 2009 in vitro study on cytotrophoblasts cells has found cytoxic effects in exposure of BPA doses from 0.0002 to 0.2 micrograms per millilitre and concluded this finding "suggests that exposure of placental cells to low doses of BPA may cause detrimental effects, leading in vivo to adverse pregnancy outcomes such as preeclampsia, intrauterine growth restriction, prematurity and pregnancy loss"[88]

A 2009 study in rats concluded that BPA, at the reference safe limit for human exposure, was found to impact intestinal permeability and may represent a risk factor in female offspring for developing severe colonic inflammation in adulthood.[89]

A 2010 study on mice has concluded that perinatal exposure to 10 micrograms/mL of BPA in drinking water enhances allergic sensitization and bronchial inflammation and responsiveness in an animal model of asthma.[90]

[edit] Studies on humans

[edit] Lang study and heart disease

The first large study of health effects on humans associated with bisphenol A exposure was published in September 2008 by Iain Lang and colleagues in the Journal of the American Medical Association.[17][91] The cross-sectional study of almost 1,500 people assessed exposure to bisphenol A by looking at levels of the chemical in urine. The authors found that higher bisphenol A levels were significantly associated with heart disease, diabetes, and abnormally high levels of certain liver enzymes. An editorial in the same issue notes that while this preliminary study needs to be confirmed and cannot prove causality, there is precedent for analogous effects in animal studies, which "add[s] biological plausibility to the results reported by Lang et al."[23]

A later similar study performed by the same group of scientists, published in January 2010, confirmed, despite of lower concentrations of BPA in the second study sample, an associated increased risk for heart disease but not for diabetes or liver enzymes.[92]

[edit] Other studies

Studies have associated recurrent miscarriage with BPA serum concentrations,[93] oxidative stress and inflamattion in postmenopausal women with urinary concentrations,[94] externalizing behaviors in two-year old children, especially among female children, with mother's urinary concentrations,[95] altered hormone levels in men[96][97] and declining male sexual function[98] with urinary concentrations.


[edit] Historical studies

The first evidence of the estrogenicity of bisphenol A came from experiments on rats conducted in the 1930s,[99][100] but it was not until 1997 that adverse effects of low-dose exposure on laboratory animals were first reported.[11]

[edit] Low dose exposure in animals

Dose (µg/kg/day) Effects (measured in studies of mice or rats,
descriptions (in quotes) are from Environmental Working Group)[101][102]		 Study Year
0.025 "Permanent changes to genital tract" 2005[103]
0.025 "Changes in breast tissue that predispose cells to hormones and carcinogens" 2005[104]
1 long-term adverse reproductive and carcinogenic effects 2009[73]
2 "increased prostate weight 30%" 1997[105]
2 "lower bodyweight, increase of anogenital distance in both genders, signs of early puberty and longer estrus." 2002[106]
2.4 "Decline in testicular testosterone" 2004[107]
2.5 "Breast cells predisposed to cancer" 2007[108]
10 "Prostate cells more sensitive to hormones and cancer" 2006[109]
10 "Decreased maternal behaviors" 2002[110]
30 "Reversed the normal sex differences in brain structure and behavior" 2003[111]
50 Adverse neurological effects occur in non-human primates 2008[41]
50 Disrupts ovarian development 2009[74]

The current U.S. human exposure limit set by the EPA is 50 µg/kg/day.[112]


[edit] Xenoestrogen

There is evidence that bisphenol A functions as a xenoestrogen by binding strongly to estrogen-related receptor γ (ERR-γ).[113] This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER).[113] BPA binding to ERR-γ preserves its basal constitutive activity.[113] It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.[113]

Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta, explaining reports of high bisphenol A accumulation in this tissue.[114]

[edit] Human exposure sources

Bisphenol A has been known to be leached from the plastic lining of canned foods[115] and, to a lesser degree,[citation needed] polycarbonate plastics, especially those that are cleaned with harsh detergents or used to contain acidic or high-temperature liquids. A recent Health Canada study found that the majority of canned soft drinks it tested had low, but measurable levels of bisphenol A.[116] This exposure through metal cans is due to the fact that BPA is an ingredient in the internal coating of food and beverage metal cans used to protect the food from direct contact with metal. While most human exposure is through diet, exposure can also occur through air and through skin absorption.[117]

Free BPA is found in high concentration in thermal paper and carbonless copy paper, which would be expected to be more available for exposure than BPA bound into resin or plastic.[15][118][119] Popular uses of thermal paper include airline tickets, event and cinema tickets, labels, and point of sale applications (receipts). While there is little concern for dermal absorption of BPA, free BPA can readily be transferred to skin and residues on hands can be ingested.[16]

Studies by the CDC found bisphenol A in the urine of 95% of adults sampled in 1988–1994[120] and in 93% of children and adults tested in 2003–04.[121] Infants fed with liquid formula are among the most exposed, and those fed formula from polycarbonate bottles can consume up to 13 micrograms of bisphenol A per kg of body weight per day (μg/kg/day; see table below).[122] The most sensitive animal studies show effects at much lower doses, while the EPA considers exposures up to 50 µg/kg/day to be safe.[101][123] In 2009, a study found that drinking from polycarbonate bottles increased urinary bisphenol A levels by two thirds, from 1.2 micrograms/gram creatinine to 2 micrograms/gram creatinine.[124]

Consumer groups recommend that people wishing to lower their exposure to bisphenol A avoid canned food and polycarbonate plastic containers (which shares resin identification code 7 with many other plastics) unless the packaging indicates the plastic is bisphenol A-free.[125] The National Toxicology Panel recommends avoiding microwaving food in plastic containers, putting plastics in the dishwasher, or using harsh detergents, to avoid leaching.[126]

A 2009 small US study funded by the EWG has detected an average of 2.8 ng/mL BPA in the blood of 9 out of the 10 umbilical cords tested.[127]

In the US and Canada, BPA has been found in infant liquid formula in concentrations varying from 0.48 to 11 ng/g.[128][129] BPA has been rarely found in infant powder formula (only 1 of 14).[128]

In the US consumption of soda, school lunches, and meals prepared outside the home was statistically significantly associated with higher urinary BPA.[130]

A 2010 study of Austrian, Swiss and German population has suggested polycarbonate (PC) baby bottles as the most prominent role of exposure for infants, and canned food for adults and teenagers.[131]

Population Estimated daily bisphenol A intake, μg/kg/day.
Table adapted from the National Toxicology Program Expert Panel Report.[10]
Infant (0–6 months)
formula-fed
1–11
Infant (0–6 months)
breast-fed
0.2–1
Infant (6–12 months)
1.65–13
Child (1.5–6 years)
0.043–14.7
Adult
0.008–1.5

[edit] Pharmacokinetics

There's no agreement between scientists of a physiologically-based pharmacokinetic (PBPK) BPA model for humans. The effects of BPA on an organism depends on how much free BPA is available and for how long cells are exposed to it. Glucuronidation in the liver, by conjugation with glucuronic acid to form the metabolite BPA-glucuronide (BPAG),[16] reduces the amount of free BPA, however BPAG can be deconjugated by beta-glucuronidase, an enzyme present in high concentration in placenta and other tissues[132][133]. Free BPA can also be inactivated by sulfation, a process that can also be reverted by arylsulfatase C.[132]

The best test methods for studying BPA effects are currently under discussion with scientists sharing different opinions.[134]

A 2010 review of 80+ biomonitoring studies concluded that the general population is internally exposed to significant amounts of unconjugated BPA (in the ng/ml blood range).[135]

A 2009 research has found that some drugs, like naproxen, salicylic acid, carbamazepine and mefenamic acid can, in vitro, significantly inhibit BPA glucuronidation.[136]

A 2010 study on rats embryos has found that genistein may enhance developmental toxicity of BPA.[137]

[edit] Environmental risk

In general, studies have shown that BPA can affect growth, reproduction and development in aquatic organisms. Among freshwater organisms, fish appear to be the most sensitive species. Evidence of endocrine-related effects in fish, aquatic invertebrates, amphibians and reptiles has been reported at environmentally relevant exposure levels lower than those required for acute toxicity. There is a widespread variation in reported values for endocrine-related effects, but many fall in the range of 1μg/L to 1 mg/L.[16]

BPA can contaminate the environment either directly or through degradation of products containing BPA, such as ocean-borne plastic trash.[138]

As an environmental contaminant this compound interferes with nitrogen fixation at the roots of leguminous plants associated with the bacterial symbiont Sinorhizobium meliloti. Despite a half-life in the soil of only 1–10 days, its ubiquity makes it an important pollutant.[139] According to Environment Canada, "initial assessment shows that at low levels, bisphenol A can harm fish and organisms over time. Studies also indicate that it can currently be found in municipal wastewater."[140]

A 2009 review of the biological impacts of plasticizers on wildlife published by the Royal Society with a focus on annelids (both aquatic and terrestrial), molluscs, crustaceans, insects, fish and amphibians concluded that BPA have been shown to affect reproduction in all studied animal groups, to impair development in crustaceans and amphibians and to induce genetic aberrations.[141]

[edit] Government and industry response

[edit] World Health Organization

Arguing uncertainty of possible adverse health effects of low dose BPA exposure, especially on the nervous system and on behaviour, and also the differences of exposure of very young children, the WHO announced in November 2009 that it would organize an expert consultation in 2010 to assess BPA safety.[53]

[edit] Australia and New Zealand

The Australia and New Zealand Food Safety Authority (Food Standards Australia New Zealand) does not see any health risk with bisphenol A baby bottles if the manufacturer's instructions are followed. Levels of exposure are very low and do not pose a significant health risk. It added that “the move by overseas manufacturers to stop using BPA in baby bottles is a voluntary action and not the result of a specific action by regulators.”[1] It suggests the use of glass baby bottles if parents have any concerns.[142]

[edit] Canada

In April 2008, Health Canada assessed that the chemical may pose some risk to infants[143] and proposed classifying the chemical as "'toxic' to human health and the environment."[144]

After the release of that assessment, Canadian Health Minister Tony Clement announced Canada's intent to ban the import, sale, and advertisement of polycarbonate baby bottles containing bisphenol A due to safety concerns, and investigate ways to reduce BPA contamination of baby formula packaged in metal cans. While the agency concluded that human exposures were less than levels believed to be unsafe, the margin of safety was not high enough for formula-fed infants.[24][145] Around the same time, Wal-Mart announced that it was immediately ceasing sales in all its Canadian stores of food containers, water and baby bottles, sippy cups, and pacifiers containing bisphenol A, and that it would phase out baby bottles made with it in U.S. stores by early 2009.[146] Nalgene also announced it will stop using the chemical in its products,[147] and Toys-R-Us said it too will cease selling baby bottles made from it.[148] Subsequent news reports showed many retailers removing polycarbonate drinking products from their shelves.[149]


The federal government has formally declared bisphenol A a hazardous substance as of October 2008 and is now placed on its list of toxic substances. Health officials wrote in Canada Gazette that "It is concluded that bisphenol A be considered as a substance that may be entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health."[150] The federal ministries of health and the environment announced they would seek to restrict imports, sales and advertising of polycarbonate baby bottles containing BPA.[151]

In its statement Gc.ca released on 18 October 2008, Health Canada noted that “bisphenol A exposure to newborns and infants is below levels that cause effects” and that the “general public need not be concerned”.

[edit] Europe

[edit] European Union

The updated 2008 European Union Risk Assessment Report on bisphenol A, published in June 2008 by the European Commission and European Food Safety Authority (EFSA) concluded that bisphenol A-based products, such as polycarbonate plastic and epoxy resins, are safe for consumers and the environment when used as intended.[152] By October 2008, after the Lang Study was published, the EFSA issued a statement concluding that the study provided no grounds to revise the current TDI (Tolerable Daily Intake) level for BPA of 0.05 mg/kg bodyweight.[153]

A 2009 scientific study criticized the European risk assessment processes of endocrine disruptors, including BPA.[154]

On 22 December 2009 the EU Environment ministers released a statement expressing concerns over recent studies showing adverse effects of exposure to endocrine disrupters.[155]

The EFSA is scheduled to release another opinion on BPA by May 2010.[156]

[edit] Denmark

In May 2009, the Danish parliament passed a resolution to ban the use of BPA in baby bottles, which has not been enacted by April 2010. In March 2010 a temporary ban was declared by the Health Minister[157]

[edit] Belgium

On March 2010, senator Philippe Mahoux proposed legislation to ban BPA in food contact plastics.[158]

[edit] France

On 5 February 2010, the French Food Safety Agency (AFSSA) questioned the previous assessments of the health risks of BPA, especially in regard to behavioral effects observed in rat pups following exposure in utero and during the first months of life.[159][160] On April 2010 the AFFSA suggested the adoption of better labels for food products containing BPA.[161]

On 24 March 2010 French Senate unanimously approved a proposition of law to ban BPA from baby bottles, the proposition still depends of Assembly approval.[162]

[edit] Germany

On 19 September 2008, the German Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung, BfR) stated that there was no reason to change the current risk assessment for bisphenol A on the basis of the Lang Study.[163]

In October, 2009, the German environmental organization Bund für Umwelt und Naturschutz Deutschland requested a ban on BPA for children's products, especially pacifiers,[164] and products that make contact with food.[165] In response, some manufacturers voluntarily removed the problematic pacifiers from the market.[166]

[edit] Netherlands

On 6 November 2008, the Dutch Food and Consumer Product Safety Authority (VWA), stated in a newsletter that baby bottles made from polycarbonate plastic do not release measurable concentrations of bisphenol A and therefore are safe to use.[167]

[edit] Switzerland

In February 2009 the Swiss Federal Office for Public Health, based on reports of other health agencies, stated that the intake of bisphenol A from food represents no risk to the consumer, including newborns and infants. However, in the same statement it advised for proper use of polycarbonate baby bottles and listed alternatives.[168]

[edit] Sweden

By May 2010 the Swedish Chemicals Agency asked for a BPA ban in baby bottles but the Swedish Food Safety Authority prefers to wait the expected European Food Safety Authority's updated review. The Minister of Environment said to wait the EFSA review but not for too long.[169][170]

[edit] UK

In December 2009 responding to a letter from a group of seven scientists that urged the UK Government to ‘adopt a standpoint consistent with the approach taken by other Governments who have ended the use of BPA in food contact products marketed at children’[171] the UK Food Standards Agency reaffirmed in January 2009 their view that ‘exposure of UK consumers to BPA from all sources, including food contact materials, was well below levels considered harmful’.[172]

[edit] United States

[edit] September 2008

In September, the National Toxicology Program finalized their report on bisphenol A, finding "some concern", mid-point of a five-level scale, that infants were at risk from exposure to the chemical.[29]

At that time, the FDA reassured consumers that current limits were safe, but convened an outside panel of experts to review the issue. The Lang study was also released that month, and David Melzer, a co-author of the study, presented the results of the study before the FDA panel.[173]

The editorial accompanying the Lang study's publication in JAMA criticized the FDA's assessment of bisphenol A: "A fundamental problem is that the current ADI [acceptable daily intake] for BPA is based on experiments conducted in the early 1980s using outdated methods (only very high doses were tested) and insensitive assays. More recent findings from independent scientists were rejected by the FDA, apparently because those investigators did not follow the outdated testing guidelines for environmental chemicals, whereas studies using the outdated, insensitive assays (predominantly involving studies funded by the chemical industry) are given more weight in arriving at the conclusion that BPA is not harmful at current exposure levels."[23]


[edit] March 2009

Sunoco, a producer of gasoline and chemicals, is now refusing to sell the chemical to companies for use in food and water containers for children younger than 3, saying it can't be certain of the compound's safety. Sunoco plans to require its customers to guarantee that the chemical will not be used in children's food products.[174]

The six largest US companies which commercialize baby bottles decided to stop using bisphenol A in their products.[175] Suffolk County, New York banned baby beverage containers made with bisphenol A.[176]

On March 13 leaders from the House and Senate proposed legislation to ban bisphenol A.[177]

In the same month, Rochelle Tyl, author of two studies used by FDA to assert BPA safety in August 2008, said those studies didn't claim that BPA is safe since they weren't designed to cover all aspects of the chemical's effects.[178]

[edit] May 2009

The first US jurisdictions to pass regulations limiting or banning BPA were Minnesota and Chicago. Minnesota's regulation takes effect in 2010, "manufacturers of ... children's products containing BPA may not sell them in the state after Jan. 1, 2010. The ban extends to all retailers in the state a year later." The products impacted are known as sippy cups and baby bottles.[179] The City of Chicago adopted a similar ban shortly thereafter. Coverage of Chicago's ban in the news showed a relentless opposition by the industry. A Chicago Tribune article noted an up-hill battle while passing legislation, "[industry officials] used FDA’s position on the issue when they tried to block the city’s measure."[180]

In May 2009 the Washington Post accused the manufacturers of food and beverage containers and some of their biggest customers of trying to devise a public relations and lobbying strategy to block government BPA bans.[181]

[edit] June 2009

In June 2009, the FDA announced the decision to reconsider the BPA safety levels.[182]

Connecticut was the first US state to ban bisphenol A from infant formula and baby food containers, as well from any reusable food or beverage container.[183]

[edit] July 2009

The California Environmental Protection Agency's Developmental and Reproductive Toxicant Identification Committee unanimously voted against placing Bisphenol A on the state's list of chemicals that are believed to cause reproductive harm. The panel, although concerned over the growing scientific research showing BPA's reproductive harm in animals, found that there was insufficient data of the effects in humans.[184] Critics point out that the same panel failed to add second-hand smoke to the list until 2006, and only one chemical was added to the list in the last three years.[185]

[edit] August 2009

On August 3, Massachusetts' Department of Public Health advised mothers to take certain actions to prevent possible health impact in children. Mothers with children up to two years old were advised to limit exposure by avoiding products that might contain BPA, such as plastic drinking bottles and other plastic materials with recycling codes of 7 or 3.[186]

The Milwaukee Journal Sentinel, as part of an ongoing investigative series into BPA and its effects, revealed plans by the Society of the Plastics Industry to execute a major public relations blitz to promote BPA, including plans to attack and discredit those who report or comment negatively on the monomer and its effects.[187][188]

[edit] September 2009

On September 29, the U.S. Environmental Protection Agency announced that it is evaluating BPA, and another five chemicals, for action plan development.[189]

[edit] October 2009

On October 28, the NIH announced $30,000,000 in stimulus grants to study the health effects of BPA. This money is expected to result in many peer-reviewed publications.[190]

[edit] November 2009

The Consumer Reports magazine published an analysis of BPA content in some canned foods and beverages, where in specific cases the content of a single can of food could exceed the current FDA Cumulative Exposure Daily Intake.[191][192]

[edit] January 2010

On January 15 the FDA expressed "some concern", the middle level in the scale of concerns, about the potential effects of BPA on the brain, behavior, and prostate gland in fetuses, infants, and young children and announced it was taking reasonable steps to reduce human exposure to BPA in the food supply. However, the FDA is not recommending that families change the use of infant formula or foods, as it sees the benefit of a stable source of good nutrition as outweighing the potential risk from BPA exposure.[1]

On the same date the U.S. Department of Health & Human Services released information to help parents to reduce children's BPA exposure.[193]

[edit] February 2010

According to The Milwaukee Journal Sentinel, which supports a BPA ban, after lobbyists for the chemical industry met with administration officials, the EPA delayed BPA regulation and did not include the chemical in an action plan released December 30, 2009.[194][195]

Many US states are considering some sort of BPA ban.[196]

[edit] March 2010

In March 29, the EPA declared BPA a "chemical of concern".[197][198]

[edit] April 2010

The 2008–2009 Annual Report of the President’s Cancer Panel declared: "because of the long latency period of many cancers, the available evidence argues for a precautionary approach to these diverse chemicals, which include (...) bisphenol A"[199]

[edit] See also

Search Wiktionary Look up bisphenol a in Wiktionary, the free dictionary.

[edit] References

  1. ^ a b "Update on Bisphenol A for Use in Food Contact Applications: January 2010". U.S. Food and Drug Administration. 15 January 2010. http://www.fda.gov/NewsEvents/PublicHealthFocus/ucm197739.htm. Retrieved 15 January 2010. 
  2. ^ Dianin (1891). Zhurnal russkogo fiziko-khimicheskogo obshchestva. 23. pp.  492–. 
  3. ^ Zincke, Theodor (1905). "Ueber die Einwirkung von Brom und von Chlor auf Phenole: Substitutionsprodukte, Pseudobromide und Pseudochloride". Justus Liebigs Annalen der Chemie 343: 75–99. doi:10.1002/jlac.19053430106. 
  4. ^ Uglea, Constantin V.; Ioan I. Negulescu (1991). Synthesis and Characterization of Oligomers. CRC Press. p. 103. 
  5. ^ a b c d Fiege, Helmut; Heinz-Werner Voges, Toshikazu Hamamoto, Sumio Umemura, Tadao Iwata, Hisaya Miki, Yasuhiro Fujita, Hans-Josef Buysch, Dorothea Garbe, Wilfried Paulus (2002). Phenol Derivatives. Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. 
  6. ^ Replogle, Jill (2009-07-17). "Lawmakers to press for BPA regulation". California Progress Report. http://www.californiaprogressreport.com/2009/07/committee_succe.html. Retrieved 2009-08-02. 
  7. ^ Ubelacker, Sheryl (2008-04-16). "Ridding life of bisphenol A a challenge". Toronto Star. http://www.thestar.com/article/415296. Retrieved 2009-08-02. 
  8. ^ Kroschwitz, Jacqueline I.. Kirk-Othmer encyclopedia of chemical technology. 5 (5 ed.). pp. 8. 
  9. ^ "Polycarbonate (PC) Polymer Resin". Alliance Polymers, Inc. http://www.alliancepoly.com/polycarbonate.asp. Retrieved 2009-08-02. 
  10. ^ a b c d e National Toxicology Program, U.S. Department of Health and Human Services (2007-11-26). "CERHR Expert Panel Report for Bisphenol A" (PDF). http://cerhr.niehs.nih.gov/chemicals/bisphenol/BPAFinalEPVF112607.pdf. Retrieved 2008-04-18. 
  11. ^ a b Erickson, Britt E. (June 2, 2008). "Bisphenol A under scrutiny". Chemical and Engineering News (American Chemical Society) 86 (22): 36–39. http://pubs.acs.org/isubscribe/journals/cen/86/i22/html/8622gov1.html. 
  12. ^ Byrne, Jane (22 September 2008). "Consumers fear the packaging - a BPA alternative is needed now". http://www.foodnavigator.com/Financial-Industry/Consumers-fear-the-packaging-a-BPA-alternative-is-needed-now. Retrieved 5 January 2010. 
  13. ^ Pesticideinfo.org: Bisphenol A
  14. ^ US patent 6562755 
  15. ^ a b Fukazawa, H.; Hoshino, K.; Shiozawa, T.; Matsushita, H.; Terao, Y. (2001). "Identification and quantification of chlorinated bisphenol a in wastewater from wastepaper recycling plants". Chemosphere 44 (5): 973–979. doi:10.1016/S0045-6535(00)00507-5. PMID 11513431.  edit
  16. ^ a b c d e "Bisphenol A Action Plan". U.S. Environmental Protection Agency. 29 March 2010. http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/bpa_action_plan.pdf. Retrieved 12 April 2010. 
  17. ^ a b Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D (2008). "Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults". JAMA 300 (300): 1303. doi:10.1001/jama.300.11.1303. PMID 18799442. http://jama.ama-assn.org/cgi/content/full/300.11.1303. 
  18. ^ Biello D (2008-02-19). "Plastic (not) fantastic: Food containers leach a potentially harmful chemical". Scientific American 2. http://www.sciam.com/article.cfm?id=plastic-not-fantastic-with-bisphenol-a. Retrieved 2008-04-09. 
  19. ^ Jack Snyder (2009-08-24). "Styrene Not a Human Carcinogen, Does Not Contain BPA". Styrene Information and Research Center (SIRC), Arlington, Va.. http://www.styrene.org/news_styrene_human_health/not_carcinogen_no_bpa_statement.html. Retrieved 2009-12-28. 
  20. ^ Gore, Andrea C. (June 8, 2007). Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice. Contemporary Endocrinology. Humana Press. ISBN 978-1588298300. 
  21. ^ O’Connor, JC; Chapin, RE (2003). "Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system" (Full Article). Pure Appl. Chem 75 (11–12): 2099–2123. doi:10.1351/pac200375112099. http://www.iupac.org/publications/pac/2003/pdf/7511x2099.pdf. Retrieved 2007-02-28. 
  22. ^ Okada H, Tokunaga T, Liu X, Takayanagi S, Matsushima A, Shimohigashi Y (January 2008). "Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma". Environ. Health Perspect. 116 (1): 32–8. doi:10.1289/ehp.10587. PMID 18197296. 
  23. ^ a b c vom Saal FS, Myers JP (2008). "Bisphenol A and Risk of Metabolic Disorders". JAMA 300 (300): 1353. doi:10.1001/jama.300.11.1353. PMID 18799451. http://jama.ama-assn.org/cgi/content/full/300.11.1353. 
  24. ^ a b Draft Screening Assessment for The Challenge Phenol, 4,4' -(1-methylethylidene)bis- (Bisphenol A)Chemical Abstracts Service Registry Number 80-05-7. Health Canada, 2008.
  25. ^ Ginsberg G, Rice DC (2009). "Does Rapid Metabolism Ensure Negligible Risk from Bisphenol A?". EPH 117 (11): 1639–1643. doi:10.1289/ehp.0901010. http://www.ehponline.org/members/2009/0901010/0901010.html. 
  26. ^ Beronius, A.; Rudén, C.; Håkansson, H.; Hanberg, A. (2009). "Risk to all or none?-A comparative analysis of controversies in the health risk assessment of Bisphenol A". Reproductive toxicology (Elmsford, N.Y.) 29 (2): 132–146. doi:10.1016/j.reprotox.2009.11.007. PMID 19931376.  edit
  27. ^ Endocrine Society released scientific statement on endocrine-disrupting chemicals
  28. ^ vom Saal FS, Akingbemi BT, Belcher SM, et al (2007). "Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure". Reprod. Toxicol. 24 (2): 131–8. doi:10.1016/j.reprotox.2007.07.005. PMID 17768031. 
  29. ^ a b c Since you asked - Bisphenol A: Questions and Answers about the Draft National Toxicology Program Brief on Bisphenol A, National Institute of Environmental Health Sciences website.
  30. ^ Elobeid, M.; Allison, D. (Oct 2008). "Putative environmental-endocrine disruptors and obesity: a review". Current opinion in endocrinology, diabetes, and obesity 15 (5): 403–408. doi:10.1097/MED.0b013e32830ce95c. ISSN 1752-296X. PMID 18769210.  edit
  31. ^ Rubin, B.; Soto, A. (May 2009). "Bisphenol A: Perinatal exposure and body weight". Molecular and cellular endocrinology 304 (1-2): 55–62. doi:10.1016/j.mce.2009.02.023. ISSN 0303-7207. PMID 19433248.  edit
  32. ^ Heindel, J.; Vom Saal, F. (May 2009). "Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity". Molecular and cellular endocrinology 304 (1-2): 90–96. doi:10.1016/j.mce.2009.02.025. ISSN 0303-7207. PMID 19433253.  edit
  33. ^ Newbold, R.; Padilla-Banks, E.; Jefferson, W. (May 2009). "Environmental estrogens and obesity". Molecular and cellular endocrinology 304 (1-2): 84–89. doi:10.1016/j.mce.2009.02.024. ISSN 0303-7207. PMID 19433252.  edit
  34. ^ Grün, F.; Blumberg, B. (May 2009). "Endocrine disrupters as obesogens". Molecular and cellular endocrinology 304 (1-2): 19–29. doi:10.1016/j.mce.2009.02.018. ISSN 0303-7207. PMID 19433244.  edit
  35. ^ Panzica, G.; Viglietti-Panzica, C.; Mura, E.; Quinn Mj, J.; Lavoie, E.; Palanza, P.; Ottinger, M. (2007). "Effects of xenoestrogens on the differentiation of behaviorally-relevant neural circuits". Frontiers in neuroendocrinology 28 (4): 179–200. doi:10.1016/j.yfrne.2007.07.001. PMID 17868795.  edit
  36. ^ Richter, C.; Birnbaum, L.; Farabollini, F.; Newbold, R.; Rubin, B.; Talsness, C.; Vandenbergh, J.; Walser-Kuntz, D. et al. (2007). "In vivo effects of bisphenol a in laboratory rodent studies". Reproductive toxicology (Elmsford, N.Y.) 24 (2): 199–224. doi:10.1016/j.reprotox.2007.06.004. PMID 17683900.  edit
  37. ^ Palanza, P; Gioiosa, L; Vom Saal, FS; Parmigiani, S (2008). "Effects of developmental exposure to bisphenol a on brain and behavior in mice". Environmental research 108 (2): 150–7. doi:10.1016/j.envres.2008.07.023. PMID 18949834.  edit
  38. ^ Patisaul, H.; Polston, E. (2008). "Influence of endocrine active compounds on the developing rodent brain". Brain research reviews 57 (2): 352–362. doi:10.1016/j.brainresrev.2007.06.008. PMID 17822772.  edit
  39. ^ Ogiue-Ikeda, M.; Tanabe, N.; Mukai, H.; Hojo, Y.; Murakami, G.; Tsurugizawa, T.; Takata, N.; Kimoto, T. et al. (2008). "Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons". Brain research reviews 57 (2): 363–375. doi:10.1016/j.brainresrev.2007.06.010. PMID 17822775.  edit
  40. ^ 10.1016/j.yfrne.2008.02.002
  41. ^ a b Leranth C, Hajszan T, Szigeti-Buck K, Bober J, Maclusky NJ (September 2008). "Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates". Proc. Natl. Acad. Sci. U.S.A. 105 (37): 14187. doi:10.1073/pnas.0806139105. PMID 18768812. 
  42. ^ Layton, Lindsey (September 4, 2008). "Chemical in Plastic Is Connected to Health Problems in Monkeys". Washington Post. pp. A02. http://www.washingtonpost.com/wp-dyn/content/article/2008/09/03/AR2008090303397.html?hpid=topnews. Retrieved 2008-09-06. 
  43. ^ Brown, J. S.; Jr, (2009). "Effects of Bisphenol-A and Other Endocrine Disruptors Compared with Abnormalities of Schizophrenia: an Endocrine-Disruption Theory of Schizophrenia". Schizophrenia Bulletin 35: 256. doi:10.1093/schbul/sbm147. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643957/.  edit
  44. ^ Kiguchi, M.; Fujita, S.; Oki, H.; Shimizu, N.; Cools, A. R.; Koshikawa, N. (2008). "Behavioural characterisation of rats exposed neonatally to bisphenol-A: responses to a novel environment and to methylphenidate challenge in a putative model of attention-deficit hyperactivity disorder". Journal of Neural Transmission 115 (7): 1079. doi:10.1007/s00702-008-0044-5. PMID 18368283.  edit
  45. ^ a b Tanida, T.; Warita, K.; Ishihara, K.; Fukui, S.; Mitsuhashi, T.; Sugawara, T.; Tabuchi, Y.; Nanmori, T. et al. (2009). "Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei.". Toxicology letters 189 (1): 40–47. doi:10.1016/j.toxlet.2009.04.005. PMID 19481886.  edit
  46. ^ Poimenova, A.; Markaki, E.; Rahiotis, C.; Kitraki, E. (2010). "Corticosterone - regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A.". Neuroscience 167 (3): 741–749. doi:10.1016/j.neuroscience.2010.02.051. PMID 20219646.  edit
  47. ^ Suzuki; Mizuo, K; Miyagawa, K; Narita, M (2005). "Exposure to bisphenol-A affects the rewarding system in mice". Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 25 (3): 125–8. PMID 16045194.  edit
  48. ^ Jones, D.; Miller, G. (2008). "The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction". Biochemical pharmacology 76 (5): 569–581. doi:10.1016/j.bcp.2008.05.010. PMID 18555207.  edit
  49. ^ Zhou, R.; Zhang, Z.; Zhu, Y.; Chen, L.; Sokabe, M.; Chen, L. (2009). "Deficits in development of synaptic plasticity in rat dorsal striatum following prenatal and neonatal exposure to low-dose bisphenol A". Neuroscience 159 (1): 161–171. doi:10.1016/j.neuroscience.2008.12.028. PMID 19162132.  edit
  50. ^ Zoeller, R. (2007). "Environmental chemicals impacting the thyroid: targets and consequences". Thyroid : official journal of the American Thyroid Association 17 (9): 811–817. doi:10.1089/thy.2007.0107. PMID 17956155.  edit
  51. ^ Boas, M.; Main, K.; Feldt-Rasmussen, U. (Oct 2009). "Environmental chemicals and thyroid function: an update". Current opinion in endocrinology, diabetes, and obesity 16 (5): 385–391. doi:10.1097/MED.0b013e3283305af7. ISSN 1752-296X. PMID 19625957.  edit
  52. ^ Kashiwagi, K.; Furuno; Kitamura; Ohta; Sugihara; Utsumi; Hanada; Taniguchi et al. (2009). "Disruption of Thyroid Hormone Function by Environmental Pollutants". Journal of Health Science 55: 147. doi:10.1248/jhs.55.147. http://jhs.pharm.or.jp/data/55(2)/55_147.pdf.  edit
  53. ^ a b "BISPHENOL A (BPA) - Current state of knowledge and future actions by WHO and FAO". 27 November 2009. http://www.who.int/entity/foodsafety/publications/fs_management/No_05_Bisphenol_A_Nov09_en.pdf. Retrieved 2 December 2009. 
  54. ^ U.S.EPA, IRIS: Bisphenol A
  55. ^ Agents Reviewed by the Monographs Volumes 1–99
  56. ^ Soto, A. M.; Sonnenschein, C. (2010). "Environmental causes of cancer: endocrine disruptors as carcinogens". Nature Reviews Endocrinology. doi:10.1038/nrendo.2010.87. Lay summary.  edit
  57. ^ Brisken, C. (2008). "Endocrine Disruptors and Breast Cancer". CHIMIA International Journal for Chemistry 62: 406–409. doi:10.2533/chimia.2008.406.  edit
  58. ^ Soto, A.; Vandenberg, L.; Maffini, M.; Sonnenschein, C. (2008). "Does breast cancer start in the womb?". Basic & clinical pharmacology & toxicology 102 (2): 125–133. doi:10.1111/j.1742-7843.2007.00165.x. PMID 18226065.  edit
  59. ^ Fernandez, S. V.; Russo, J. (2009). "Estrogen and Xenoestrogens in Breast Cancer". Toxicologic Pathology 38 (1): 110. doi:10.1177/0192623309354108. PMID 19933552.  edit
  60. ^ Jenkins, S.; Raghuraman, N.; Eltoum, I.; Carpenter, M.; Russo, J.; Lamartiniere, C. A. (2009). "Oral Exposure to Bisphenol a Increases Dimethylbenzanthracene-Induced Mammary Cancer in Rats" (Free full text). Environmental Health Perspectives. doi:10.1289/ehp.11751. http://ehp.niehs.nih.gov/members/2009/11751/11751.html.  edit
  61. ^ Betancourt, A.; Mobley, J.; Russo, J.; Lamartiniere, C. (2010). "Proteomic Analysis in Mammary Glands of Rat Offspring Exposed In Utero to Bisphenol A.". Journal of proteomics 73 (6): 1241–1253. doi:10.1016/j.jprot.2010.02.020. PMID 20219716.  edit
  62. ^ Lapensee, E. W.; Lapensee, C. R.; Fox, S.; Schwemberger, S.; Afton, S.; Ben-Jonathan, N. (2010). "Bisphenol a and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells". Cancer Letters 290 (2): 167. doi:10.1016/j.canlet.2009.09.005. PMID 19796866. Lay summary.  edit
  63. ^ Zhu, H.; Xiao, X.; Zheng, J.; Zheng, S.; Dong, K.; Yu, Y. (2009). "Growth-promoting effect of bisphenol a on neuroblastoma in vitro and in vivo☆". Journal of Pediatric Surgery 44 (4): 672–680. doi:10.1016/j.jpedsurg.2008.10.067. PMID 19361625.  edit
  64. ^ Zheng, J.; Xiao, X.; Liu, J.; Zheng, S.; Yin, Q.; Yu, Y. (2007). "Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cells☆". Environmental Toxicology and Pharmacology 24: 189–193. doi:10.1016/j.etap.2007.05.003.  edit
  65. ^ Zhu, H; Zheng, J; Xiao, X; Zheng, S; Dong, K; Liu, J; Wang, Y (2010). "Environmental endocrine disruptors promote invasion and metastasis of SK-N-SH human neuroblastoma cells". Oncology reports 23 (1): 129–39. PMID 19956873.  edit
  66. ^ Nagel, SC; Vom Saal, FS; Thayer, KA; Dhar, MG; Boechler, M; Welshons, WV (1997). "Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol a and octylphenol". Environmental health perspectives (Brogan & Partners) 105 (1): 70–6. doi:10.2307/3433065. PMID 9074884. PMC 1469837. http://jstor.org/stable/3433065.  edit
  67. ^ Timms, B.; Howdeshell, K.; Barton, L.; Bradley, S.; Richter, C.; Vom Saal, F. (2005). "Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra". Proceedings of the National Academy of Sciences of the United States of America 102 (19): 7014–7019. doi:10.1073/pnas.0502544102. PMID 15867144.  edit
  68. ^ Ho, S.; Tang, W.; Belmonte De Frausto, J.; Prins, G. (2006). "Developmental exposure to estradiol and bisphenol a increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4". Cancer research 66 (11): 5624–5632. doi:10.1158/0008-5472.CAN-06-0516. PMID 16740699.  edit
  69. ^ Richter, C.; Taylor, J.; Ruhlen, R.; Welshons, W.; Vom Saal, F. (2007). "Estradiol and Bisphenol a stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells". Environmental health perspectives 115 (6): 902–908. doi:10.1289/ehp.9804. PMID 17589598.  edit
  70. ^ Prins, G. (2008). "Developmental exposure to bisphenol a increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated". Fertility and Sterility 89: e41-e41. doi:10.1016/j.fertnstert.2007.12.023.  edit
  71. ^ Bagchi, Debasis (2010). Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods. Wiley. p. 319. 
  72. ^ Dolinoy, D. C.; Huang, D.; Jirtle, R. L. (2007). "Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development". Proceedings of the National Academy of Sciences 104: 13056. doi:10.1073/pnas.0703739104.  edit
  73. ^ a b Newbold, R.; Jefferson, N.; Padilla-Banks, E. (Jun 2009). "Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life". Environmental health perspectives 117 (6): 879–885. doi:10.1289/ehp.0800045. ISSN 0091-6765. PMID 19590677.  edit
  74. ^ a b Adewale, B.; Jefferson, N.; Newbold, R.; Patisaul, B. (Jun 2009). "Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin Releasing Hormone Neurons" (Free full text). Biology of reproduction 81 (4): 690–699. doi:10.1095/biolreprod.109.078261. ISSN 0006-3363. PMID 19535786. http://www.biolreprod.org/cgi/pmidlookup?view=long&pmid=19535786.  edit
  75. ^ Study Finds Reproductive Health Effects From Low Doses of Bisphenol-A
  76. ^ Bosquiazzo, L.; Varayoud, J.; Muñoz-De-Toro, M.; Luque, H.; Ramos, G. (Aug 2009). "Effects of Neonatal Exposure to Bisphenol a on Steroid Regulation of Vascular Endothelial Growth Factor Expression and Endothelial Cell Proliferation in the Adult Rat Uterus" (Free full text). Biology of reproduction 82 (1): 86–95. doi:10.1095/biolreprod.109.078543. ISSN 0006-3363. PMID 19696011. http://www.biolreprod.org/cgi/pmidlookup?view=long&pmid=19696011.  edit
  77. ^ Monje, L.; Varayoud, J.; Muñoz-De-Toro, M.; Luque, H.; Ramos, G. (Jul 2009). "Neonatal exposure to bisphenol a alters estrogen-dependent mechanisms governing sexual behavior in the adult female rat". Reproductive toxicology (Elmsford, N.Y.) 28 (4): 435–442. doi:10.1016/j.reprotox.2009.06.012. ISSN 0890-6238. PMID 19577632.  edit
  78. ^ Nakagami, A.; Negishi, T.; Kawasaki, K.; Imai, N.; Nishida, Y.; Ihara, T.; Kuroda, Y.; Yoshikawa, Y. et al. (Sep 2009). "Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol a in cynomolgus monkeys (Macaca fascicularis) during early suckling period". Psychoneuroendocrinology 34 (8): 1189–1197. doi:10.1016/j.psyneuen.2009.03.005. ISSN 0306-4530. PMID 19345509.  edit
  79. ^ Huang, H.; Leung, K. (Sep 2009). "Bisphenol a downregulates CYP19 transcription in JEG-3 cells". Toxicology letters 189 (3): 248–252. doi:10.1016/j.toxlet.2009.06.853. ISSN 0378-4274. PMID 19539015.  edit
  80. ^ Li; Mruk, D.; Lee, W.; Cheng, C. (2009). "Disruption of the blood-testis barrier integrity by bisphenol a in vitro: is this a suitable model for studying blood-testis barrier dynamics?". The international journal of biochemistry & cell biology 41 (11): 2302–2314. doi:10.1016/j.biocel.2009.05.016. PMID 19497385.  edit
  81. ^ http://dx.doi.org/10.1093/humrep/dep381
  82. ^ Ryan, B.; Hotchkiss, A.; Crofton, K.; Gray Jr, L. (2010). "In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats". Toxicological sciences : an official journal of the Society of Toxicology 114 (1): 133–148. doi:10.1093/toxsci/kfp266. PMID 19864446.  edit
  83. ^ vom Saal, F. S.; Akingbemi, B.; Belcher, S.; Crain, D.; Crews, D.; Guidice, L.; Hunt, P.; Leranth, C. et al. (2010). "Flawed Experimental Design Reveals the Need for Guidelines Requiring Appropriate Positive Controls in Endocrine Disruption Research.". Toxicological sciences : an official journal of the Society of Toxicology 115 (2): 612–613; author 613 614–613. doi:10.1093/toxsci/kfq048. PMID 20164146.  edit
  84. ^ Gray LE, Ryan B, Hotchkiss AK, Crofton KM (March 2010). "Rebuttal of "Flawed Experimental Design Reveals the Need for Guidelines Requiring Appropriate Positive Controls in Endocrine Disruption Research" by (Vom Saal 2010)". Toxicol Sci. doi:10.1093/toxsci/kfq073. PMID 20207694. http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=20207694. 
  85. ^ Bromer, J. G.; Zhou, Y.; Taylor, M. B.; Doherty, L.; Taylor, H. S. (2010). "Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response". The FASEB Journal. doi:10.1096/fj.09-140533. Lay summary.  edit
  86. ^ "More Troubling News About BPA / Science News". www.sciencenews.org. http://www.sciencenews.org/view/generic/id/44577/title/More_troubling_news_about_BPA. Retrieved 2009-06-11. 
  87. ^ "Hormone experts worried about plastics, chemicals - Yahoo! News". news.yahoo.com. http://news.yahoo.com/s/nm/20090611/hl_nm/us_bisphenol_2. Retrieved 2009-06-11. 
  88. ^ Benachour, N.; Aris, A. (2009). "Toxic effects of low doses of Bisphenol-A on human placental cells.". Toxicology and applied pharmacology 241 (3): 322–328. doi:10.1016/j.taap.2009.09.005. PMID 19769995. Lay summary.  edit
  89. ^ Braniste, V.; Jouault, A.; Gaultier, E.; Polizzi, A.; Buisson-Brenac, C.; Leveque, M.; Martin, P.; Theodorou, V. et al. (2009). "Impact of oral bisphenol a at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats" (PDF). Proceedings of the National Academy of Sciences of the United States of America 107 (1): 448–453. doi:10.1073/pnas.0907697107. PMID 20018722. PMC 2806743. http://www.pnas.org/content/early/2009/12/10/0907697107.full.pdf.  edit
  90. ^ Midoro-Horiuti, T.; Tiwari, R.; Watson, C.; Goldblum, R. (2010). "Maternal bisphenol a exposure promotes the development of experimental asthma in mouse pups". Environmental health perspectives 118 (2): 273–277. doi:10.1289/ehp.0901259. PMID 20123615.  edit
  91. ^ Newscientist.com Plastic bottle chemical linked to heart disease
  92. ^ Melzer, D.; Rice, N. E.; Lewis, C.; Henley, W. E.; Galloway, T. S.; Zhang, B. (2010). "Association of Urinary Bisphenol a Concentration with Heart Disease: Evidence from NHANES 2003/06" (pdf). PLoS ONE 5: e8673. doi:10.1371/journal.pone.0008673. http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0008673&representation=PDF. Lay summary.  edit
  93. ^ Sugiura-ogasawara, M.; Ozaki, Y.; Sonta, S. -I.; Makino, T.; Suzumori, K. (2005). "Exposure to bisphenol a is associated with recurrent miscarriage". Human reproduction (Oxford, England) 20 (8): 2325–2329. doi:10.1093/humrep/deh888. PMID 15947000.  edit
  94. ^ Yang, J.; Hong, C.; Oh, Y.; Park, S.; Kim, H.; Leem, H.; Ha, H. (Aug 2009). "Bisphenol a exposure is associated with oxidative stress and inflammation in postmenopausal women". Environmental research 109 (6): 797–801. doi:10.1016/j.envres.2009.04.014. ISSN 0013-9351. PMID 19464675.  edit
  95. ^ Braun, J.; Yolton, K.; Dietrich, K.; Hornung, R.; Ye, X.; Calafat, A.; Lanphear, B. (2009). "Prenatal Bisphenol a Exposure and Early Childhood Behavior". Environmental Health Perspectives. doi:10.1289/ehp.0900979.  edit
  96. ^ Meeker, J. D.; Calafat, A. M.; Hauser, R. (2009). "Urinary Bisphenol a Concentrations in Relation to Serum Thyroid and Reproductive Hormone Levels in Men from an Infertility Clinic". Environmental Science & Technology 44: 091223134144053. doi:10.1021/es9028292.  edit
  97. ^ Mendiola, J.; Jørgensen, N.; Andersson, A. M.; Calafat, A. M.; Ye, X.; Redmon, J. B.; Drobnis, E. Z.; Wang, C. et al. (2010). "Are Environmental Levels of Bisphenol a Associated with Reproductive Function in Fertile Men?". Environmental Health Perspectives. doi:10.1289/ehp.1002037.  edit
  98. ^ Li DK, Zhou Z, Miao M, et al. (May 2010). "Relationship between Urine Bisphenol-A (BPA) Level and Declining Male Sexual Function". J Androl. doi:10.2164/jandrol.110.010413. PMID 20467048. 
  99. ^ E. C. Dodds and Wilfrid Lawson, "Synthetic Œstrogenic Agents without the Phenanthrene Nucleus", Nature, 137 (1936), 996.
  100. ^ E. C. Dodds and W. Lawson, Proceedings of the Royal Society of London, Series B, Biological Sciences, 125, #839 (27-IV-1938), pp. 222–232.
  101. ^ a b Mittelstaedt, Martin (2007-04-07). "'Inherently toxic' chemical faces its future". Globe & Mail. http://www.theglobeandmail.com/servlet/story/RTGAM.20070406.wbisphenolA0407/BNStory/National/. Retrieved 2007-04-07. 
  102. ^ This table is adapted from: EWG, 2007. "Many studies confirm BPA's low-dose toxicity across a diverse range of toxic effects," Environmental Working Group Report: A Survey of Bisphenol A in U.S. Canned Foods. Accessed November 4th, 2007 at http://www.ewg.org/node/20941. All studies included in this table where judged by the CEHRH panel to be at least of moderate usefulness for assessing the risk of BPA to human reproduction.
  103. ^ Markey CM, Wadia PR, Rubin BS, Sonnenschein C, Soto AM (2005). "Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract". Biol. Reprod. 72 (6): 1344–51. doi:10.1095/biolreprod.104.036301. PMID 15689538. http://www.biolreprod.org/cgi/pmidlookup?view=long&pmid=15689538. 
  104. ^ Muñoz-de-Toro M, Markey CM, Wadia PR, et al (2005). "Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice". Endocrinology 146 (9): 4138–47. doi:10.1210/en.2005-0340. PMID 15919749. http://endo.endojournals.org/cgi/pmidlookup?view=long&pmid=15919749. 
  105. ^ Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV (1997). "Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol". Environ. Health Perspect. 105 (1): 70–6. doi:10.2307/3433065. PMID 9074884. 
  106. ^ Honma S, Suzuki A, Buchanan DL, Katsu Y, Watanabe H, Iguchi T (2002). "Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction". Reprod. Toxicol. 16 (2): 117–22. doi:10.1016/S0890-6238(02)00006-0. PMID 11955942. http://linkinghub.elsevier.com/retrieve/pii/S0890623802000060. 
  107. ^ Akingbemi BT, Sottas CM, Koulova AI, Klinefelter GR, Hardy MP (2004). "Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells". Endocrinology 145 (2): 592–603. doi:10.1210/en.2003-1174. PMID 14605012. http://endo.endojournals.org/cgi/pmidlookup?view=long&pmid=14605012. 
  108. ^ Murray TJ, Maffini MV, Ucci AA, Sonnenschein C, Soto AM (2007). "Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure". Reprod. Toxicol. 23 (3): 383–90. doi:10.1016/j.reprotox.2006.10.002. PMID 17123778. PMC 1987322. http://linkinghub.elsevier.com/retrieve/pii/S0890-6238(06)00263-2. 
  109. ^ Ho SM, Tang WY, Belmonte de Frausto J, Prins GS (2006). "Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4". Cancer Res. 66 (11): 5624–32. doi:10.1158/0008-5472.CAN-06-0516. PMID 16740699. PMC 2276876. http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16740699. 
  110. ^ Palanza PL, Howdeshell KL, Parmigiani S, vom Saal FS (2002). "Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice". Environ. Health Perspect. 110 Suppl 3: 415–22. PMID 12060838. PMC 1241192. http://ehpnet1.niehs.nih.gov/docs/2002/suppl-3/415-422palanza/abstract.html. 
  111. ^ Kubo K, Arai O, Omura M, Watanabe R, Ogata R, Aou S (2003). "Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats". Neurosci. Res. 45 (3): 345–56. doi:10.1016/S0168-0102(02)00251-1. PMID 12631470. http://linkinghub.elsevier.com/retrieve/pii/S0168010202002511. 
  112. ^ EPA (Environmental Protection Agency). 1988. Oral RfD Assessment: Bisphenol A. Integrated Risk Information System.
  113. ^ a b c d Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y (October 2007). "Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma". J. Biochem. 142 (4): 517–24. doi:10.1093/jb/mvm158. PMID 17761695. 
  114. ^ Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y (July 2009). "Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform". J. Biochem. 146 (1): 113–22. doi:10.1093/jb/mvp049. PMID 19304792. 
  115. ^ "Environmental Working Group". http://www.ewg.org/reports/bisphenola. Retrieved 2007-03-07. 
  116. ^ Health Canada. "Survey of Bisphenol A in Canned Drink Products". http://www.hc-sc.gc.ca/fn-an/securit/packag-emball/bpa/bpa_survey-enquete-can-eng.php. Retrieved 2009-03-13. 
  117. ^ Lang IA Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace, Robert B, Melzer, D (2008). "Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults". JAMA 300 (300): 1303. doi:10.1001/jama.300.11.1303. PMID 18799442. http://jama.ama-assn.org/cgi/content/full/300.11.1303. 
  118. ^ Raloff, Janet (2009-10-07). "Concerned About BPA: Check Your Receipts". Society for Science and the Public. http://www.sciencenews.org/view/generic/id/48084/title/Concerned_about_BPA_Check_your_receipts. Retrieved 2009-10-07. 
  119. ^ Gehring, Martin; Tennhardt, L., Vogel, D., Weltin, D., Bilitewski, B. (2004) (PDF). Bisphenol A Contamination of Wastepaper, Cellulose and Recycled Paper Products. Waste Management and the Environment II. WIT Transactions on Ecology and the Environment, vol. 78. WIT Press. http://rcswww.urz.tu-dresden.de/~gehring/deutsch/dt/vortr/040929ge.pdf. Retrieved 2009-10-15. Lay summary. 
  120. ^ Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham LL (2005). "Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population". Environ. Health Perspect. 113 (4): 391–5. PMID 15811827. PMC 1278476. http://ehpnet1.niehs.nih.gov/members/2004/7534/7534.html. 
  121. ^ Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008). "Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004". Environ. Health Perspect. 116 (1): 39–44. doi:10.1289/ehp.10753. PMID 18197297. 
  122. ^ "European Food Safety Authority Opinion" (Abstract). http://www.efsa.europa.eu/en/science/afc/afc_opinions/bisphenol_a.html. Retrieved 2007-02-28. 
  123. ^ Bisphenol A - United States Environmental Protection Agency
  124. ^ Carwile JL, Luu HT, Bassett LS, Driscoll DA, Yuan C, Chang JY, Ye X, Calafat AM, Michels KB (2009). "Use of Polycarbonate Bottles and Urinary Bisphenol A Concentrations". Environ. Health Perspect.. doi:10.1289/ehp.0900604. http://www.ehponline.org/members/2009/0900604/0900604.pdf. 
  125. ^ War of the Sciences Air Date: Week of September 19, 2008 - Ashley Ahearn, Living on Earth
  126. ^ FDA Weighs Safety Of Bisphenol A
  127. ^ "Cord Blood Contaminants in Minority Newborns". Environmental Working Group. 2009. http://www.ewg.org/files/2009-Minority-Cord-Blood-Report.pdf. Retrieved 2 December 2009. 
  128. ^ a b Ackerman, L.; Noonan, G.; Heiserman, W.; Roach, J.; Limm, W.; Begley, T. (2010). "Determination of Bisphenol a in U.S. Infant Formulas: Updated Methods and Concentrations". Journal of agricultural and food chemistry 58 (4): 100126132743092. doi:10.1021/jf903959u. PMID 20102208.  edit
  129. ^ Cao, X.; Dufresne, G.; Belisle, S.; Clement, G.; Falicki, M.; Beraldin, F.; Rulibikiye, A. (2008). "Levels of bisphenol a in canned liquid infant formula products in Canada and dietary intake estimates". Journal of agricultural and food chemistry 56 (17): 7919–7924. doi:10.1021/jf8008712. PMID 18702469.  edit
  130. ^ Lakind, J. S.; Naiman, D. Q. (2010). "Daily intake of bisphenol a and potential sources of exposure: 2005–2006 National Health and Nutrition Examination Survey". Journal of Exposure Science and Environmental Epidemiology. doi:10.1038/jes.2010.9.  edit
  131. ^ Von Goetz, N.; Wormuth, M.; Scheringer, M.; Hungerbühler, K. (2010). "Bisphenol A: How the Most Relevant Exposure Sources Contribute to Total Consumer Exposure.". Risk analysis : an official publication of the Society for Risk Analysis 30: 473. doi:10.1111/j.1539-6924.2009.01345.x. PMID 20136739.  edit
  132. ^ a b Gary Ginsberg and Deborah C. Rice (November 2009). "Does Rapid Metabolism Ensure Negligible Risk from Bisphenol A?". Environmental Health Perspectives 117 (11): 1639–1643. http://www.ehponline.org/members/2009/0901010/0901010.pdf. Retrieved 2009-11-16. 
  133. ^ Nishikawa, M.; Iwano, H.; Yanagisawa, R.; Koike, N.; Inoue, H.; Yokota, H. (2010). "Placental Transfer of Conjugated Bisphenol a and Subsequent Reactivation in the Rat Fetus". Environmental health perspectives. doi:10.1289/ehp.0901575. PMID 20382578.  edit
  134. ^ Borrell, Brendan (21 April). "Toxicology: The big test for bisphenol A". Nature 464: 1122-1124. doi:10.1038/4641122a. http://www.nature.com/news/2010/100421/full/4641122a.html. Retrieved 21 April 2010. 
  135. ^ Vandenberg, L. N.; Chauhoud, I.; Heindel, J. J.; Padmanabhan, V.; Paumgartten, F. J. R.; Schoenfelder, G. (2010). "Urinary, Circulating and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A". Environmental Health Perspectives. doi:10.1289/ehp.0901716.  edit
  136. ^ Verner, M.; Magher, T.; Haddad, S. (2009). "High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol a and nonylphenol in rats". Xenobiotica; the fate of foreign compounds in biological systems 00 (2): 091116055959032. doi:10.3109/00498250903383334. PMID 19916736.  edit
  137. ^ Xing, L.; Xu, Y.; Xiao, Y.; Shang, L.; Liu, R.; Wei, X.; Jiang, J.; Hao, W. (2010). "Embryotoxic and teratogenic effects of the combination of bisphenol a and genistein on in vitro cultured postimplantation rat embryos". Toxicological Sciences. doi:10.1093/toxsci/kfq081.  edit
  138. ^ Barry, Carolyn (2009-08-20). "Plastic Breaks Down in Ocean, After All -- And Fast". National Geographic News. http://news.nationalgeographic.com/news/2009/08/090820-plastic-decomposes-oceans-seas.html. Retrieved 2009-08-30. 
  139. ^ Fox, J.E., J. Gulledge, E. Engelhaupt, M.E. Burrow & J.A. McLachlan (2007). "Pesticides reduce symbiotic efficiency of nitrogen-fixing rhizobia and host plants". Proc. Nat. Acad. Sci. 104 (24): 10282–7. doi:10.1073/pnas.0611710104. PMID 17548832. 
  140. ^ Bisphenol A Fact Sheet, Government of Canada. Assessed April 19, 2008.
  141. ^ Oehlmann, J.; Schulte-Oehlmann, U.; Kloas, W.; Jagnytsch, O.; Lutz, I.; Kusk, O.; Wollenberger, L.; Santos, M. et al. (Jul 2009). "A critical analysis of the biological impacts of plasticizers on wildlife". Philosophical transactions of the Royal Society of London. Series B, Biological sciences 364 (1526): 2047–2062. doi:10.1098/rstb.2008.0242. ISSN 0962-8436. PMID 19528055.  edit
  142. ^ "Baby’s bottles and bisphenol A". New Zealand Food Safety Authority. May 2008. http://www.nzfsa.govt.nz/consumers/chemicals-nutrients-additives-and-toxins/bisphenol-a.htm. Retrieved 2009-03-21. 
  143. ^ Morrissey, Susan R. (April 23, 2008). "Banning Bisphenol A In Baby Bottles: Canada moves toward restricting the chemical; Congress proposes similar legislation". Chemical and Engineering News. http://pubs.acs.org/cen/news/86/i17/8617news4.html. .
  144. ^ Government of Canada Takes Action on Another Chemical of Concern: Bisphenol A, Chemical Substances, Health Canada. Accessed April 19, 2008.
  145. ^ The government will evaluate whether the ban will become law in October 2008. "Government of Canada Takes Action on Another Chemical of Concern: Bisphenol A". http://www.chemicalsubstanceschimiques.gc.ca/challenge-defi/bisphenol-a_e.html. Retrieved 2008-04-18. 
  146. ^ Wal-Mart to pull baby bottles made with chemical BPA: Washington Post, Market Watch, April 18, 2008.
  147. ^ Bottle Maker to Stop Using Plastic Linked to Health Concerns, New York Times, April 18, 2008.
  148. ^ "Toys 'R' Us to phase out bisphenol A baby bottles". CBC News. 2008-04-22. http://www.cbc.ca/consumer/story/2008/04/22/bottles-bpa.html. Retrieved 2008-04-22. 
  149. ^ Canoe.ca, Politics: Bisphenol A water-bottle removal expanding among Canadian retailers
  150. ^ "Toxic status possible for bisphenol A in Canada". CBC News. 2008-10-17. http://www.cbc.ca/health/story/2008/10/17/bpa-toxic.html. Retrieved 2008-10-17. 
  151. ^ "Canada moves to ban bisphenol A in baby bottles". CBC News. 2008-10-18. http://www.cbc.ca/canada/story/2008/10/18/bpa-regulations.html. Retrieved 2008-10-20. 
  152. ^ Rapporteur: United Kingdom. (2008). JRC.it Updated European Risk Assessment Report: 4,4’-ISOPROPYLIDENEDIPHENOL (BISPHENOL-A) FINAL APPROVED VERSION AWAITING FOR PUBLICATION. Press release.
  153. ^ Europa.eu
  154. ^ Beronius; Rudén, C.; Hanberg, A.; Håkansson, H. (2009). "Health risk assessment procedures for endocrine disrupting compounds within different regulatory frameworks in the European Union". Regulatory toxicology and pharmacology : RTP 55 (2): 111–122. doi:10.1016/j.yrtph.2009.05.019. PMID 19500631.  edit
  155. ^ "Council conclusions on combination effects of chemicals". Brussels: Council of The European Union. 22 December 2009. http://www.consilium.europa.eu/uedocs/NewsWord/en/envir/112043.doc. Retrieved 30 December 2009. 
  156. ^ "Bisphenol A update: EFSA calls meeting and invites contributions from Member States". European Food Safety Authority. 2 February 2010. http://www.efsa.europa.eu/en/press/news/cef100202.htm. Retrieved 8 February 2010. 
  157. ^ "Danmark forbyder giftigt stof i sutteflasker" (in danish). http://www.dr.dk/Nyheder/Politik/2010/03/26/113304.htm. Retrieved 26 March 2010. 
  158. ^ "Negen op tien zuigflessen zijn gevaarlijk". 5/03/2010. http://nieuws.be.msn.com/buitenland/artikel.aspx?cp-documentid=152421106. Retrieved 8 March 2010. 
  159. ^ "Bisphenol A: AFSSA recommends the development of new assessment methods". 5 February 2010. http://www.afssa.fr/PM9100B6I0.htm. Retrieved 8 February 2010. 
  160. ^ "Opinion of the French Food Safety Agency on the critical analysis of the results of a study of the toxicity of bisphenol A on the development of the nervous system together with other recently-published data on its toxic effects". French Food Safety Agency. 29 January 2010. http://www.afssa.fr/cgi-bin/countdocs.cgi?Documents/MCDA2009sa0270EN.pdf. Retrieved 8 February 2010. 
  161. ^ "Afssa: informations sur le Bisphénol A" (in french). Le Figaro. 27 April 2010. http://www.lefigaro.fr/flash-actu/2010/04/27/97001-20100427FILWWW00356-afssa-informations-sur-le-bisphenol-a.php. Retrieved 7 May 2010. 
  162. ^ "Les sénateurs votent la suspension de la commercialisation des biberons au Bisphenol A". Le Monde. 24 March 2010. http://www.lemonde.fr/planete/article/2010/03/24/les-senateurs-votent-la-suspension-de-la-commercialisation-des-biberons-au-bisphenol-a_1324041_3244.html. Retrieved 24 March 2010. 
  163. ^ Bund.de (German)
  164. ^ "Schnuller geben hormonell wirksames Bisphenol A ab. BUND fordert Verbot der Chemikalie für Babyartikel" (in german). http://www.bund.net/nc/bundnet/presse/pressemitteilungen/detail/zurueck/pressemitteilungen/artikel/schnuller-geben-hormonell-wirksames-bisphenol-a-ab-bund-fordert-verbot-der-chemikalie-fuer-babyarti. Retrieved 2009-10-15. 
  165. ^ "Chemikalie in Schnullern entdeckt" (in german). 2009-10-01. http://www.derwesten.de/nachrichten/wp/2009/10/1/news-135346902/detail.html. Retrieved 2009-10-02. 
  166. ^ "Bisphenol-A: Kehrtwende" (in German). MedizinAuskunft. 4 November 2009. http://www.medizinauskunft.de/artikel/aktuell/2009/04_11_bisphenol_a.php. Retrieved 4 November 2009. 
  167. ^ VWA.nl (Dutch)
  168. ^ Admin.ch (German)
  169. ^ "Minister kör över Livsmedelsverket" (in swedish). http://www.dagenshandel.se/dh/DagensH.nsf/0/CEEB5E81FEE99BDFC1257720002F04A9. Retrieved 13 May 2010. 
  170. ^ "BioNut researcher on ban of bisphenol A (BPA)". 10 May 2010. http://ki.se/ki/jsp/polopoly.jsp?d=25844&a=100803&l=en&newsdep=25844. Retrieved 13 May 2010. 
  171. ^ Smith, Rebecca (December 1, 2009). "Ban chemical linked to cancer in baby bottles: campaigners". Telegraph. http://www.nomorebpa.org.uk/news/US_Acts_On_BPA_And_Baby%20_Bottles.php. Retrieved 16 February 2010. 
  172. ^ "US Acts on BPA and Baby Bottles while UK Food Standards Agency dismisses concerns". Breast Cancer UK. 18 January 2009. http://www.nomorebpa.org.uk/news/US_Acts_On_BPA_And_Baby%20_Bottles.php. Retrieved 16 February 2010. 
  173. ^ Layton, Lindsey (September 16, 2008). "Study Links Chemical BPA to Health Problems". Washington Post. pp. A03. http://www.washingtonpost.com/wp-dyn/content/story/2008/09/16/ST2008091601215.html?sid=ST2008091601215&s_pos=list. Retrieved 2008-09-17. 
  174. ^ Matthew Perrone (12 March 2009). "Sunoco restricts sales of chemical used in bottles". Associated Press. http://www.google.com/hostednews/ap/article/ALeqM5gOPl1ZUc7b5Zxrt5oXVoyFC24GTQD96SMQH80. Retrieved 2009-03-13. 
  175. ^ No BPA For Baby Bottles In U.S. 6 Makers Announce Decision on Chemical - By Lyndsey Layton, March 6, 2009; Page A06, Washington Post
  176. ^ County bans baby bottle plastic with BPA By Karen Forman, March 05, 2009, northshoreoflongisland.com
  177. ^ Bills Would Ban BPA From Food and Drink Containers, Milwaukee Journal Sentinel, March 14, 2009; Page A04, Washington Post
  178. ^ Scientists reject FDA assertion of BPA's safety
  179. ^ Sternberg, Bob von (2009-05-08). "State bans chemical in baby bottles". Star Tribune. http://www.startribune.com/lifestyle/health/44586267.html. Retrieved 2009-07-11. 
  180. ^ "Chicago BPA ban: Chicago bans sale of baby bottles, sippy cups with dangerous chemical ... linked to diabetes, cancer and other illnesses". 2009-05-14. http://archives.chicagotribune.com/2009/may/14/local/chi-chicago-bpa-baby-bottles-14may14. Retrieved 2009-08-04. 
  181. ^ Strategy Being Devised To Protect Use of BPA
  182. ^ FDA to Revisit Decision on Safety of BPA
  183. ^ Bodach, Jill (2009-06-05). "Connecticut first state to ban BPA". The Hour (The Hour Publishing Co.). http://www.thehour.com/story/470418. Retrieved 2009-09-09. 
  184. ^ "Calif. regulators will not list Bisphenol A under Prop. 65, call for more study". http://www.latimes.com/business/nationworld/wire/sns-ap-us-california-bpa,0,3478515.story. Retrieved 2009-07-19. 
  185. ^ California won't warn public about bisphenol A
  186. ^ "Public Health Advisory Regarding Bisphenol A (BPA)". Commonwealth of Massachusetts. http://www.mass.gov/?pageID=eohhs2pressrelease&L=4&L0=Home&L1=Government&L2=Departments+and+Divisions&L3=Department+of+Public+Health&sid=Eeohhs2&b=pressrelease&f=090803_bpa_advisory&csid=Eeohhs2. Retrieved 2009-08-04. 
  187. ^ "BPA industry fights back", from Milwaukee Journal Sentinel, August 23, 2009
  188. ^ "'Watchdog' advocates for BPA", from Milwaukee Journal Sentinel, August 23, 2009
  189. ^ "Existing Chemical Action Plans". http://www.epa.gov/oppt/existingchemicals/pubs/ecactionpln.html. Retrieved 2009-10-01. 
  190. ^ Sarewitz D (December 2009). "World view: A tale of two sciences". Nature 462 (7273): 566. doi:10.1038/462566a. PMID 19956236. 
  191. ^ "Concern over canned foods". Consumer Reports. December 2009. http://www.consumerreports.org/cro/magazine-archive/december-2009/food/bpa/overview/bisphenol-a-ov.htm. Retrieved 2009-11-04. 
  192. ^ "Significant bisphenol A levels found in canned food". 2009-11-04. http://www.foodmag.com.au/Article/Significant-bisphenol-A-levels-found-in-canned-food/504393.aspx. Retrieved 2009-11-04. 
  193. ^ "Bisphenol A (BPA) Information for Parents". U.S. Department of Health & Human Services. 15 January 2010. http://www.hhs.gov/safety/bpa/. Retrieved 15 January 2010. 
  194. ^ Kissinger, Meg (14 February 2010). "Regulator waffles on bisphenol A". Journal Sentinel. http://www.jsonline.com/watchdog/watchdogreports/84321857.html. Retrieved 17 February 2010. 
  195. ^ "EPA delays action on suspect chemical". United Press International. 14 February 2010. http://www.upi.com/Top_News/US/2010/02/14/EPA-delays-action-on-suspect-chemical/UPI-37321266190180/. Retrieved 17 February 2010. 
  196. ^ Koch, Wendy (16 February 2010). "Bans sought for chemical BPA in baby, toddler products". USA Today. http://content.usatoday.com/communities/greenhouse/post/2010/02/bans-sought-for-chemical-bpa-in-baby-toddler-products/1. Retrieved 17 February 2010. 
  197. ^ "EPA to Scrutinize Environmental Impact of Bisphenol A". US Environmental Protection Agency. 29 March 2010. http://yosemite.epa.gov/opa/admpress.nsf/d0cf6618525a9efb85257359003fb69d/78110048d7f696d1852576f50054241a!OpenDocument. Retrieved 12 April 2010. 
  198. ^ "Bisphenol A (BPA) Action Plan Summary". US Environmental Protection Agency. http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/bpa.html. Retrieved 12 April 2010. 
  199. ^ Reuben, Suzanne H. (April 2010). "Annual Report for 2008-2009". National Cancer Institute. http://deainfo.nci.nih.gov/advisory/pcp/pcp08-09rpt/PCP_Report_08-09_508.pdf. Retrieved 6 May 2010. 

[edit] External links

v • d • e
Health issues of plastics and Polyhalogenated compounds (PHC)'s
Plasticizers: Phthalates
DIBP · DBP · BBP (BBzP) · DIHP · DEHP (DOP) · DIDP · DINP
Miscellaneous plasticizers
Monomers
Bisphenol A (BPA, in Polycarbonates) · Vinyl chloride (in PVC)
Miscellaneous additives incl. PHC's
PBDEs · PCBs · Organotins  · PFCs
Health issues
Miscellanea
Retrieved from "http://en.wikipedia.org/wiki/Bisphenol_A"
Personal tools
Namespaces
Variants
Actions
Navigation
Interaction
Toolbox
Print/export
Languages