| Title | Platform | Year | Company | Composer |
| Sam & Max Hit the Road | PC | 1993 | LucasArts Entertainment | Clint Bajakian, Michael Land, Peter McConnell |
| Sandwarriors | PC | 1996 | Astros Productions | Chris Adams |
| Sanitarium | PC | 1998 | DreamForge Intertainment | Stephen Bennett, James C. McMenamy |
| Scaler | PS2, XBOX, GCN | 2004 | Artificial Mind & Movement | Etienne Mialet, Frederic Vercheval, Arrogant Music |
| Scorcher | PC, SAT | 1996 | Scavenger | Jesper Kyd |
| Scumball | C64 | 1987 | Software Creations | Tim Follin |
| Scurge: Hive | GBA, DS | 2006 | Orbital Media | Jake Kaufman |
| Second Sight | GCN, PS2, XBOX, PC | 2004 | Free Radical Design | Graeme Norgate |
| Secret of Evermore | SNES | 1995 | Square Co., Ltd. | Jeremy Soule |
| Secret Weapons Over Normandy | PC, PS2, XBOX | 2003 | Totally Games / LucasArts | Michael Giacchino |
| Sensible Soccer | SCD | 1994 | Sensible | Tim Wright |
| Sentinel | ZX | 1987 | Software Creations | Tim Follin |
| Sesame Street 1 2 3 | NES | 1989 | Rare Ltd. | David Wise |
| Sesame Street A B C | NES | 1989 | Rare Ltd. | David Wise |
| Sesame Street ABC/123 | NES | 1991 | Rare Ltd. | David Wise |
| Seven Kingdoms | PC | 1997 | Enlight | Bjørn Lynne |
| Seven Kingdoms II: The Frythan Wars | PC | 1999 | Enlight | Bjørn Lynne |
| Shade: Wrath of Angels | PC | 2004 | Black Element Software | Jaroslav Kaný |
| Shadow Madness | PSX | 1999 | Crave Entertainment | Brad Spear |
| Shadow Man | PSX, N64, DC, PC | 1999 | Acclaim | Tim Haywood |
| Shadow of the Beast | PCE | 1992 | Reflections Interactive / Psygnosis | David Whittaker, Tim Wright |
| Shadow of the Beast II | AMI | 1990 | Psygnosis | Tim Wright |
| Shadow of the Beast III | AMI | 1992 | Psygnosis | Tim Wright |
| Shanghai | AMI | 1993 | ? | Bjørn Lynne |
| Shantae | GBC | 2002 | WayForward Technologies | Jake Kaufman |
| Shaq Fu | SNES, GEN, AMI | 1994 | Delphine Software International | Raphaël Gesqua (SNES, GEN), Rob Balderstone (Amiga) |
| Shattered Galaxy | PC | 2001 | KRU Games | Jesper Kyd |
| Shrek Super Party | PS2, XBOX, GCN | 2002 | Mass Media | Chris Tilton |
| Siege of Avalon | PC | 2000 | Digital Tome | Bjørn Lynne, Carl Leon |
| Silent Service | NES | 1989 | Rare Ltd. | David Wise |
| Silver Surfer | NES | 1990 | Software Creations | Tim Follin, Geoff Follin |
| SimCity 2000 | AMI | 1994 | Maxis | Sue Kasper, Mark Knight |
| SimCity 3000 | PC | 1999 | Maxis Software | Kirk Casey, Anna Karney, Robert Kauker, Kent Jolly, Jerry Martin, Marc Russo |
| SimCity 4 | PC | 2003 | Maxis Software | Jerry Martin, Marc Russo, Robert Kauker, Kent Jolly, The Humble Brothers, Kirk Casey, Anna Karney, Walt Szalva, Bob Marshall, Michael Land |
| SimCity Societies | PC | 2007 | EA | Trevor Morris |
| SimLife | AMI | 1993 | Maxis | Russell Lieblich, Steve Hales, Mark Knight |
| Skeleton Krew | AMI, CD32 | 1995 | Core Design | Martin Iveson |
| Skeleton Krew | GEN | 1995 | Core Design | Nathan McCree |
| Skullmonkeys | PSX | 1998 | The Neverhood | Terry Scott Taylor |
| Sky Digital TV games | TV | 2001 | Open Interactive | Bjørn Lynne, ? |
| Sky Shark | C64, NES ('89) | 1988 | Software Creations | Tim Follin |
| Sky Warrior | MOB | 2005 | VRG Studio | Bjørn Lynne |
| SkyRoads | PC | 1993 | BlueMoon Software | Ott Aaloe, Hasso Brück |
| Slalom | NES | 1987 | Rare Ltd. | David Wise |
| Slam City with Scottie Pippen | SCD, 32X, PC | 1995 | Digital Pictures, Inc. | John Baker, Scottie Pippen, Jellybean Benitez, Ed Terry, Kangol |
| Sly 2: Band of Thieves | PS2 | 2004 | Sucker Punch Productions LLC | Bill Wolford, Peter McConnell |
| Sly 3: Honor Among Thieves | PS2 | 2005 | Sucker Punch Productions LLC | Bill Wolford, Peter McConnell |
| Sly Cooper and the Thievius Raccoonus | PS2 | 2002 | Sucker Punch Productions LLC | Ashif Hakik, Boyd Post, Ian Rodia |
| Sly Spy | AMI | 1989 | Software Creations | Geoff Follin, Tim Follin |
| Sly Spy | AST, C64, ZX | 1989 | Software Creations | Geoff Follin |
| Small Soldiers | PSX | 1998 | DreamWorks / EA | Michael Giacchino |
| Small Soldiers: Squad Commander | PC | 1998 | Hasbro Interactive / DreamWorks | Michael Giacchino |
| Snake Rattle N Roll | GEN | 1993 | Rare Ltd. | David Wise |
| Snake Rattle N Roll | NES | 1990 | Rare Ltd. | David Wise |
| Sneaky Snakes | GB | 1991 | Rare Ltd. | David Wise |
| SOCOM: U.S. Navy SEALs | PS2 | 2002 | SCEA | Jeremy Soule, Julian Soule |
| Solar Invasion | ZX | 1989 | Mastertronic | Tim Follin |
| Solar Jetman | C64 | 1991 | Software Creations | Geoff Follin |
| Solar Jetman | NES | 1990 | Rare Ltd. | David Wise |
| Soldier | PC | 2001 | Sinister Games / SouthPeak Interactive | Jesper Kyd, Jun Mizumachi |
| Solstice | NES | 1990 | Software Creations | Tim Follin |
| Sonic CD | SCD | 1993 | Sega | Spencer Nilsen, David Young, Sterling, Armando Peraza, Bobby Vega |
| Soul of the Ultimate Nation | PC | 2005 | Webzen | Howard Shore |
| Soulstar | SCD | 1994 | Core Design | Nathan McCree |
| Space Empire: Starfury | PC | 2003 | Malfador Machinations | Bjørn Lynne |
| Spider-Man and The X-Men in Arcade's Revenge | SNES | 1992 | Software Creations | Tim Follin, Geoff Follin |
| Spidertronic | AMI | 1988 | Ère Informatique | Stéphane Picq |
| Spin Jam | PSX | 2000 | Empire Interactive | Bjørn Lynne |
| Spinning For Gold | ONL | 2005 | Gamesys | Bjørn Lynne |
| Splinter Cell: Chaos Theory | PC | 2005 | Ubisoft | Amon Tobin, Jesper Kyd, (Licensed) |
| Spot | GB | 1990 | Software Creations | Geoff Follin |
| SPY Fox 2: Some Assembly Required | PC | 1999 | Humongous Entertainment | Tom McGurk, Geoff Kirk |
| SPY Fox in Cheese Chase | PC | 1998 | Humongous Entertainment | Julian Soule |
| SPY Fox in Dry Cereal | PC | 1997 | Humongous Entertainment | Julian Soule, Geoff Kirk |
| SPY Fox in Hold the Mustard | PC | 1999 | Humongous Entertainment | Scott Lloyd Shelley |
| SPY Fox: Operation Ozone | PC | 2001 | Humongous Entertainment | Tom McGurk, Geoff Kirk |
| Spy Hunter / Super Sprint | GBA | 2005 | Black Lantern Studios | Chad Seiter, Jake Kaufman |
| Spy Hunter: Nowhere to Run | PS2, XBOX | 2006 | Terminal Reality / Midway | Cris Velasco, Sascha Dikiciyan, Alexander Brandon |
| Star Firebirds | ZX | 1985 | Firebird | Tim Follin |
| Star Fox Adventures | GCN | 2002 | Rare Ltd. | David Wise, Ben Cullum |
| Star Paws | ZX | 1988 | Software Projects | Tim Follin |
| Star Wars: Bounty Hunter | PS2, GCN | 2002 | LucasArts | Jeremy Soule, (Original SW Music) |
| Star Wars: Empire at War | PC | 2006 | Petroglyph | Frank Klepacki |
| Star Wars: Empire at War - Forces of Corruption | PC | 2006 | Petroglyph | Frank Klepacki |
| Star Wars: Knights of the Old Republic | XBOX, PC | 2003 | LucasArts | Jeremy Soule, (Original SW Music) |
| Star Wars: Knights of the Old Republic II - The Sith Lords | XBOX, PC | 2004 | LucasArts | Mark Griskey, Jeremy Soule, (Original SW Music) |
| Starsky & Hutch | PC, PS2, XBOX, GCN | 2003 | Minds-Eye Productions | Tim Follin, Dave Sullivan, Matthew Costello |
| Starwinder: The Ultimate Space Race | PSX | 1996 | Mindscape | Joseph Kolkovich |
| Stuart Little 2 | PSX | 2002 | Magenta Software | Game Audio Ltd. (Steve Owen) |
| Stunt GP | PC, DC, PS2 | 2001 | Team17 | Bjørn Lynne, Marc Pattison |
| Sub-Terrania | GEN | 1993 | Zyrinx | Jesper Kyd |
| Subterranean Stryker | ZX | 1985 | Insight | Tim Follin |
| Super 1 Karting Simulation | PC | 2000 | Interactive Entertainment | Escape Committee |
| Super Glove Ball | NES | 1990 | Rare Ltd. | David Wise |
| Super Obliteration | AMI | 1993 | David Papworth | Bjørn Lynne |
| Super Off Road | NES | 1989 | Rare Ltd. | David Wise |
| Super Off Road | SNES | 1992 | Software Creations | Tim Follin, Geoff Follin |
| Super R.C. Pro-Am | GB | 1991 | Rare Ltd. | David Wise |
| Superbike 2000 | PC, PSX | 2000 | EA | McSleazy, Mark Knight |
| Superhero | AMI | ? | Psygnosis | Mike Clarke |
| Supersonic Racers | PSX | 1996 | Supersonic Software / Mindscape | Gerard Gourley, Mark Knight |
| Supreme Commander | PC | 2007 | Gas Powered Games | Jeremy Soule |
| Supreme Commander: Forged Alliance | PC | 2007 | Gas Powered Games | Jeremy Soule |
| Swagman | PSX | 1997 | Core Design | Nathan McCree |
| Synaesthete | PC | 2007 | DigiPen | William Towns |
| Syndicate | PC, AMI, SNES, etc. | 1993 | Bullfrog | Russell Shaw |
| Syndicate Wars | PC, PSX | 1996 | Bullfrog | Adrian Moore, Russell Shaw |
| Syndicate: American Revolt | PC, AMI | 1993 | Bullfrog | Russell Shaw |
| Syphon Filter | PSX | 1999 | 989 Studios | Chuck Doud |
| Syphon Filter 2 | PSX | 2000 | 989 Studios | Chuck Doud |
| Syphon Filter 3 | PSX | 2001 | SCEA | Christopher Stevens |