CGRP is a chemical in the body associated with the pain of cluster headache and migraine. Researchers have identified some compounds that block CGRP production and act as headache abortives. These compounds are undergoing testing to determine if they are suitable for widespread use. Because they do not have strong vaso-constricting action, CGRP blockers may be useful for individuals that cannot take triptans.

The most widely studied CGRP blocker is referred to as BIBN4096BS. In recent trials, it was 66% effective when given orally. It seems to have both abortive and preventive properties. source (cache)

At least two natural therapies have been shown to reduce CGRP levels. One is Sangre de Grado, or blood of the dragon. The other is a traditional Japanese herbal formula known as Keishi-bukuryo-gan. Although the mechanism of action of these is not fully understood, there is evidence that the oligomeric proanthocyanidins (and possibly anthocyanin plant pigments) are key to the action of Sangre de Grado.

Topiramate (aka Topomax) has been shown to reduce CGRP levels (abstract (cache))

Release of CGRP tends to occur with the release of Substance P, Nitric Oxide and other chemicals that compromise an inflammatory cascade.

I have written software that scans the pubmed database and used it to find out what natural therapies might be used to control CGRP. That list can be found at www.shrubmed.com/CGRP.html

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